RT Journal Article T1 Impact of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients: a nationwide study in Spain. A1 Paredes, Igor A1 Castaño Leon, Ana Maria A1 Lagares, Alfonso A1 Jimenez Roldan, Luis A1 Perez-Nuñez, Angel A1 González-Leon, Pedro A1 Delgado-Fernandez, Juan A1 Eiriz, Carla A1 García-Pérez, Daniel A1 Moreno-Gomez, Luis Miguel A1 Esteban-Sinovas, Olga A1 Delgado-López, Pedro A1 Martín-Alonso, Javier A1 Kaen, Ariel A1 Tirado-Caballero, Jorge A1 Ordóñez Carmona, Marta A1 Arteaga Romero, Francisco A1 Gonzalez Pombo, Marta A1 Alén, José F A1 Gil-Simoes, Ricardo A1 Torres, Cristina V A1 Navas Garcia, Marta A1 Blasco, Guillermo A1 Frade-Porto, Natalia A1 González-Tarno, Patricia A1 Martin Segura, Adrian A1 Gelabert-Gonzalez, Miguel A1 Menendez Cortezon, Beatriz A1 Rodriguez Botana, Brais A1 Pérez-Alfayate, Rebeca A1 Fernandez Garcia, Carla A1 Ferrandez Pujante, Borja A1 Vargas-Jiménez, Andres A1 Cotúa, Carlos A1 de la Lama, Adolfo A1 Calero, Lourdes A1 Ruiz-Juretschke, Fernando A1 Garcia Leal, Roberto A1 Valera Mele, Marc A1 Casitas Hernando, Vicente A1 Rivero Martín, Belén A1 Orduna, Javier A1 Casado Pellejero, Juan A1 Fustero De Miguel, David A1 Diaz-Molina, Jorge A1 Moles Herbera, Jesus A1 Castello Ruiz, Maria Jose A1 Gomar Alba, Mario A1 Garcia Perez, Fernando A1 Hernandez Garcia, Borja Jesus A1 Villaseñor Ledezma, Javier A1 Otero Rodríguez, Álvaro A1 Ailagas, Juan José A1 Goncalves-Estella, Jesús A1 Sousa Casasnovas, Pablo A1 Pascual Argente, Daniel A1 Ruiz Martín, Laura A1 Roa Montes de Oca, Juan Carlos A1 Arandia Guzmán, Daniel A1 García Martín, Andoni A1 Torres Carretero, Luis A1 Garrido Ruíz, Patricia Alejandra A1 Calvo, Marta A1 Miranda-Lloret, Pablo A1 Rodriguez-Cadarso Suarez-Vence, Miguel A1 Anotn Oltra, Joan A1 Roca Barber, Amparo A1 Quiroz Tejada, Arnold A1 Carbayo Lozano, Guillermo A1 Bermudez Vilar, Garazi A1 Paternain Martin, Clara A1 Dela FuenteVilla, Pablo A1 Fidalgo De la Rosa, Marina A1 Sistiaga García, Íñigo L A1 Zabalo San Juan, Gorka K1 adult surgery K1 neurological injury K1 neurological oncology K1 neurosurgery AB To assess the effect of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients in Spain. The initial flood of COVID-19 patients overwhelmed an unprepared healthcare system. Different measures were taken to deal with this overburden. The effect of these measures on neurosurgical patients, as well as the effect of COVID-19 itself, has not been thoroughly studied. This was a multicentre, nationwide, observational retrospective study of patients who underwent any neurosurgical operation from March to July 2020. An exploratory factorial analysis was performed to select the most relevant variables of the sample. Univariate and multivariate analyses were performed to identify independent predictors of mortality and postoperative SARS-CoV-2 infection. Sixteen hospitals registered 1677 operated patients. The overall mortality was 6.4%, and 2.9% (44 patients) suffered a perioperative SARS-CoV-2 infection. Of those infections, 24 were diagnosed postoperatively. Age (OR 1.05), perioperative SARS-CoV-2 infection (OR 4.7), community COVID-19 incidence (cases/105 people/week) (OR 1.006), postoperative neurological worsening (OR 5.9), postoperative need for airway support (OR 5.38), ASA grade ≥3 (OR 2.5) and preoperative GCS 3-8 (OR 2.82) were independently associated with mortality. For SARS-CoV-2 postoperative infection, screening swab test Perioperative SARS-CoV-2 infection in neurosurgical patients was associated with an increase in mortality by almost fivefold. Community COVID-19 incidence (cases/105 people/week) was a statistically independent predictor of mortality. CEIM 20/217. YR 2021 FD 2021-12-10 LK https://hdl.handle.net/10668/24916 UL https://hdl.handle.net/10668/24916 LA en DS RISalud RD Apr 17, 2025