RT Journal Article
T1 Differences in maternal and neonatal cardiometabolic markers and placenta status by foetal sex. The GESTAFIT project.
A1 Aparicio, Virginia A
A1 Baena-García, Laura
A1 Flor-Alemany, Marta
A1 Martínez-González, Luis J
A1 Varela-López, Alfonso
A1 Sánchez, Cristina
A1 Quiles, José L
K1 fibroblast Growth Factor
K1 lipids
K1 newborn
K1 pregnancy
K1 telomere
K1 triglycerides
AB To explore the differences in some maternal-neonatal metabolic markers and placenta status by foetal sex. One hundred thirty-nine Caucasian pregnant women from the GESTAFIT project and their new-borns were included in the present cross-sectional study. Serum cardiometabolic markers (i.e. lipid and glycaemic profile and uric acid) were analysed at late pregnancy and at birth. In placenta, telomeres length, proportion of deleted mitochondrial-DNA and mitochondrial-DNA density, some minerals and interleukin 8, epidermal growth factor, fibroblast growth factor-2 and vascular endothelial growth factor were measured. The study was run between November 2015 and April 2018. Mothers carrying a male showed higher serum triglycerides than mothers carrying a female at late pregnancy (p  Our findings show weak differences in some cardiometabolic and placental status markers by foetal sex. Notwithstanding, we observed a slightly more proatherogenic profile in both, mothers carrying males' foetuses and male new-borns. We also found lower serum uric acid and better placenta status in mothers carrying a female. These findings indicate that foetal sex might need to be considered for a more personalized follow-up of pregnancies.
YR 2022
FD 2022
LK http://hdl.handle.net/10668/20227
UL http://hdl.handle.net/10668/20227
LA en
DS RISalud
RD Apr 6, 2025