RT Journal Article
T1 Association between Hyperacusis and Tinnitus
A1 Cederroth, Christopher R.
A1 Lugo, Alessandra
A1 Edvall, Niklas K.
A1 Lazar, Andra
A1 Lopez-Escamez, Jose-Antonio
A1 Bulla, Jan
A1 Uhlen, Inger
A1 Hoare, Derek J.
A1 Baguley, David M.
A1 Canlon, Barbara
A1 Gallus, Silvano
K1 Tinnitus
K1 Hyperacusis
K1 TMJ
K1 Headache
K1 Migraine
K1 Hearing loss
K1 Subtype
K1 Somatosensory
K1 Acúfeno
K1 Hiperacusia
K1 Articulación temporomandibular
K1 Cefalea
K1 Trastornos migrañosos
K1 Pérdida auditiva
AB Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of 3645 participants (1984 with tinnitus and 1661 without tinnitus) were enrolled via LifeGene, a study from the general Swedish population, aged 18-90 years, and provided information on socio-demographic characteristics, as well as presence of hyperacusis and its severity. Tinnitus presence and severity were self-reported or assessed using the Tinnitus Handicap Inventory (THI). Phenotypes of tinnitus with (n = 1388) or without (n = 1044) hyperacusis were also compared. Of 1661 participants without tinnitus, 1098 (66.1%) were women and 563 were men (33.9%), and the mean (SD) age was 45.1 (12.9). Of 1984 participants with tinnitus, 1034 (52.1%) were women and 950 (47.9%) were men, and the mean (SD) age was 47.7 (14.0) years. Hyperacusis was associated with any tinnitus [Odds ratio (OR) 3.51, 95% confidence interval (CI) 2.99-4.13], self-reported severe tinnitus (OR 7.43, 95% CI 5.06-10.9), and THI ≥ 58 (OR 12.1, 95% CI 7.06-20.6). The association with THI ≥ 58 was greater with increasing severity of hyperacusis, the ORs being 8.15 (95% CI 4.68-14.2) for moderate and 77.4 (95% CI 35.0-171.3) for severe hyperacusis. No difference between sexes was observed in the association between hyperacusis and tinnitus. The occurrence of hyperacusis in severe tinnitus is as high as 80%, showing a very tight relationship. Discriminating the pathophysiological mechanisms between the two conditions in cases of severe tinnitus will be challenging, and optimized study designs are necessary to better understand the mechanisms behind the strong relationship between hyperacusis and tinnitus.
PB MDPI
YR 2020
FD 2020-07-28
LK http://hdl.handle.net/10668/3942
UL http://hdl.handle.net/10668/3942
LA en
NO Cederroth CR, Lugo A, Edvall NK, Lazar A, Lopez-Escamez JA, Bulla J, et al. Association between Hyperacusis and Tinnitus. J Clin Med. 2020 Jul 28;9(8):2412
DS RISalud
RD Apr 10, 2025