RT Journal Article
T1 HLA Class II Polymorphism and Humoral Immunity Induced by the SARS-CoV-2 mRNA-1273 Vaccine.
A1 Gutiérrez-Bautista, Juan Francisco
A1 Sampedro, Antonio
A1 Gómez-Vicente, Esther
A1 Rodríguez-Granger, Javier
A1 Reguera, Juan Antonio
A1 Cobo, Fernando
A1 Ruiz-Cabello, Francisco
A1 López-Nevot, Miguel Ángel
K1 HLA associations
K1 anti-S antibodies
K1 mRNA-1273 vaccine
AB The vaccines designed against the SARS-CoV-2 coronavirus are based on the spike (S) protein. Processing of the S protein by antigen-presenting cells (APC) and its subsequent presentation to T cells is an essential part of the development of a humoral response. HLA-class II alleles are considered immune response genes because their codified molecules, expressed on the surface of APCs (macrophages, dendritic, and B cells) present antigenic peptides to T cell via their T cell receptor (TCR). The HLA-class II genes are highly polymorphic, regulating what specific peptides induce follicular helper T cells (TFH) and promote B lymphocyte differentiation into plasma or memory B cells. This work hypothesizes that the presence of certain HLA-class II alleles could be associated with the intensity of the humoral response (amount, length) to the SARS-CoV2 mRNA 1273 vaccine. We have studied the relationship between the HLA-class II typing of 87 health workers and the level of antibodies produced 30 days after vaccination. We show a possible association between the HLA-DRB1* 07:01 allele and the HLA-DRB1*07:01~DQA1*02:01~DQB1*02:02 haplotype to a higher production of antibodies 30 days after the administration of the second dose of mRNA-1273.
SN 2076-393X
YR 2022
FD 2022-03-06
LK http://hdl.handle.net/10668/21606
UL http://hdl.handle.net/10668/21606
LA en
DS RISalud
RD Apr 8, 2025