RT Journal Article
T1 Clinical outcomes of hospitalised patients with COVID-19 and chronic inflammatory and autoimmune rheumatic diseases: a multicentric matched cohort study.
A1 Pablos, Jose L
A1 Galindo, María
A1 Carmona, Loreto
A1 Lledó, Ana
A1 Retuerto, Miriam
A1 Blanco, Ricardo
A1 Gonzalez-Gay, Miguel A
A1 Martinez-Lopez, David
A1 Castrejón, Isabel
A1 Alvaro-Gracia, José M
A1 Fernández Fernández, David
A1 Mera-Varela, Antonio
A1 Manrique-Arija, Sara
A1 Mena Vázquez, Natalia
A1 Fernandez-Nebro, Antonio
A1 RIER Investigators Group, 
A1 RIER investigators group, 
K1 ankylosing
K1 arthritis
K1 autoimmune diseases
K1 epidemiology
K1 psoriatic
K1 rheumatoid
K1 spondylitis
AB The impact of inflammatory rheumatic diseases on COVID-19 severity is poorly known. Here, we compare the outcomes of a cohort of patients with rheumatic diseases with a matched control cohort to identify potential risk factors for severe illness. In this comparative cohort study, we identified hospital PCR+COVID-19 rheumatic patients with chronic inflammatory arthritis (IA) or connective tissue diseases (CTDs). Non-rheumatic controls were randomly sampled 1:1 and matched by age, sex and PCR date. The main outcome was severe COVID-19, defined as death, invasive ventilation, intensive care unit admission or serious complications. We assessed the association between the outcome and the potential prognostic variables, adjusted by COVID-19 treatment, using logistic regression. The cohorts were composed of 456 rheumatic and non-rheumatic patients, in equal numbers. Mean age was 63 (IQR 53-78) years and male sex 41% in both cohorts. Rheumatic diseases were IA (60%) and CTD (40%). Most patients (74%) had been hospitalised, and the risk of severe COVID-19 was 31.6% in the rheumatic and 28.1% in the non-rheumatic cohort. Ageing, male sex and previous comorbidity (obesity, diabetes, hypertension, cardiovascular or lung disease) increased the risk in the rheumatic cohort by bivariate analysis. In logistic regression analysis, independent factors associated with severe COVID-19 were increased age (OR 4.83; 95% CI 2.78 to 8.36), male sex (1.93; CI 1.21 to 3.07) and having a CTD (OR 1.82; CI 1.00 to 3.30). In hospitalised patients with chronic inflammatory rheumatic diseases, having a CTD but not IA nor previous immunosuppressive therapies was associated with severe COVID-19.
YR 2020
FD 2020-08-12
LK http://hdl.handle.net/10668/16102
UL http://hdl.handle.net/10668/16102
LA en
DS RISalud
RD Apr 7, 2025