RT Journal Article
T1 Clinical outcome of COVID-19 in patients with adult congenital heart disease.
A1 Schwerzmann, Markus
A1 Ruperti-Repilado, Francisco Javier
A1 Baumgartner, Helmut
A1 Bouma, Berto
A1 Bouchardy, Judith
A1 Budts, Werner
A1 Campens, Laurence
A1 Chessa, Massimo
A1 Del-Cerro-Marin, Maria Jesus
A1 Gabriel, Harald
A1 Gallego, Pastora
A1 Garcia-Orta, Rocio
A1 Gonzalez, Ana Elvira
A1 Schophuus-Jensen, Annette
A1 Ladouceur, Magalie
A1 Miranda-Barrio, Berta
A1 Morissens, Marielle
A1 Pasquet, Agnes
A1 Rueda, Joaquin
A1 van-den-Bosch, Annemien E
A1 van-der-Zwaan, Heleen Berdina
A1 Tobler, Daniel
A1 Greutmann, Matthias
K1 congenital
K1 heart defects
AB Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD. Twenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome. Of 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0). Among patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome.
PB BMJ Group
YR 2021
FD 2021-03-08
LK http://hdl.handle.net/10668/17330
UL http://hdl.handle.net/10668/17330
LA en
NO Schwerzmann M, Ruperti-Repilado FJ, Baumgartner H, Bouma B, Bouchardy J, Budts W, et al. Clinical outcome of COVID-19 in patients with adult congenital heart disease. Heart. 2021 Jul 12;107(15):1226-1232.
DS RISalud
RD Apr 18, 2025