%0 Journal Article
%A Schwerzmann, Markus
%A Ruperti-Repilado, Francisco Javier
%A Baumgartner, Helmut
%A Bouma, Berto
%A Bouchardy, Judith
%A Budts, Werner
%A Campens, Laurence
%A Chessa, Massimo
%A Del-Cerro-Marin, Maria Jesus
%A Gabriel, Harald
%A Gallego, Pastora
%A Garcia-Orta, Rocio
%A Gonzalez, Ana Elvira
%A Schophuus-Jensen, Annette 
%A Ladouceur, Magalie
%A Miranda-Barrio, Berta
%A Morissens, Marielle
%A Pasquet, Agnes
%A Rueda, Joaquin
%A van-den-Bosch, Annemien E
%A van-der-Zwaan, Heleen Berdina
%A Tobler, Daniel
%A Greutmann, Matthias
%T Clinical outcome of COVID-19 in patients with adult congenital heart disease.
%D 2021
%U http://hdl.handle.net/10668/17330
%X Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD. Twenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome. Of 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0). Among patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome.
%K congenital
%K heart defects
%~