RT Journal Article
T1 Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study.
A1 Babich, Tanya
A1 Naucler, Pontus
A1 Valik, John Karlsson
A1 Giske, Christian G
A1 Benito, Natividad
A1 Cardona, Ruben
A1 Rivera, Alba
A1 Pulcini, Celine
A1 Fattah, Manal Abdel
A1 Haquin, Justine
A1 Macgowan, Alasdair
A1 Grier, Sally
A1 Chazan, Bibiana
A1 Yanovskay, Anna
A1 Ami, Ronen Ben
A1 Landes, Michal
A1 Nesher, Lior
A1 Zaidman-Shimshovitz, Adi
A1 McCarthy, Kate
A1 Paterson, David L
A1 Tacconelli, Evelina
A1 Buhl, Michael
A1 Mauer, Susanna
A1 Rodriguez-Baño, Jesus
A1 de Cueto, Marina
A1 Oliver, Antonio
A1 de Gopegui, Enrique Ruiz
A1 Cano, Angela
A1 Machuca, Isabel
A1 Gozalo-Marguello, Monica
A1 Martinez-Martinez, Luis
A1 Gonzalez-Barbera, Eva M
A1 Alfaro, Iris Gomez
A1 Salavert, Miguel
A1 Beovic, Bojana
A1 Saje, Andreja
A1 Mueller-Premru, Manica
A1 Pagani, Leonardo
A1 Vitrat, Virginie
A1 Kofteridis, Diamantis
A1 Zacharioudaki, Maria
A1 Maraki, Sofia
A1 Weissman, Yulia
A1 Paul, Mical
A1 Dickstein, Yaakov
A1 Leibovici, Leonard
A1 Yahav, Dafna
K1 Antibiotics
K1 Antimicrobial stewardship
K1 Bacteremia
K1 Duration
K1 Pseudomonas aeruginosa
AB There is no consensus regarding optimal duration of antibiotic therapy for Pseudomonas aeruginosa bacteremia. We aimed to evaluate the impact of short antibiotic course. We present a retrospective multicenter study including patients with P. aeruginosa bacteremia during 2009-2015. We evaluated outcomes of patients treated with short (6-10 days) versus long (11-15 days) antibiotic courses. The primary outcome was a composite of 30-day mortality or bacteremia recurrence and/or persistence. Univariate and inverse probability treatment-weighted (IPTW) adjusted multivariate analysis for the primary outcome was performed. To avoid immortal time bias, the landmark method was used. We included 657 patients; 273 received a short antibiotic course and 384 a long course. There was no significant difference in baseline characteristics of patients. The composite primary outcome occurred in 61/384 patients in the long-treatment group (16%) versus 32/273 in the short-treatment group (12%) (p = 0.131). Mortality accounted for 41/384 (11%) versus 25/273 (9%) of cases, respectively. Length of hospital stay was significantly shorter in the short group [median 13 days, interquartile range (IQR) 9-21 days, versus median 15 days, IQR 11-26 days, p = 0.002]. Ten patients in the long group discontinued antibiotic therapy owing to adverse events, compared with none in the short group. On univariate and multivariate analyses, duration of therapy was not associated with the primary outcome. In this retrospective study, 6-10 days of antibiotic course for P. aeruginosa bacteremia were as effective as longer courses in terms of survival and recurrence. Shorter therapy was associated with reduced length of stay and less drug discontinuation.
PB Springer Healthcare
SN 2193-8229
YR 2022
FD 2022-05-09
LK http://hdl.handle.net/10668/21563
UL http://hdl.handle.net/10668/21563
LA en
NO Babich T, Naucler P, Valik JK, Giske CG, Benito N, Cardona R, et al. Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study. Infect Dis Ther. 2022 Aug;11(4):1505-1519.
DS RISalud
RD Apr 8, 2025