TY  - JOUR
AU  - de la Cruz-Herrera, Carlos F
AU  - Campagna, Michela
AU  - García, Maria A
AU  - Marcos-Villar, Laura
AU  - Lang, Valerie
AU  - Baz-Martínez, Maite
AU  - Gutiérrez, Sylvia
AU  - Vidal, Anxo
AU  - Rodríguez, Manuel S
AU  - Esteban, Mariano
AU  - Rivas, Carmen
PY  - 2014
DO  - 10.1074/jbc.M114.560961
SN  - 0021-9258
UR  - http://hdl.handle.net/10668/2245
T2  - The Journal of Biological Chemistry
AB  - The dsRNA-dependent kinase PKR is an interferon-inducible protein with ability to phosphorylate the α subunit of the eukaryotic initiation factor (eIF)-2 complex, resulting in a shut-off of general translation, induction of apoptosis, and inhibition...
LA  - en
PB  - American Society for Biochemistry and Molecular Biology
KW  - Double-stranded RNA (dsRNA)
KW  - Protein Kinase RNA-activated (PKR)
KW  - Sumoylation
KW  - Translation Control
KW  - Virus
KW  - Activación enzimática
KW  - Interacciones huésped-patógeno
KW  - Inmunidad innata
KW  - Mapeo peptídico
KW  - Unión proteica
KW  - ARN bicatenario
KW  - ARN viral
KW  - Proteína SUMO-1
KW  - Análisis de secuencia de proteína
KW  - Sumoilación
KW  - Replicación viral
KW  - eIF-2 quinasa
KW  - Células 3T3
KW  - Animales
KW  - Multimerización de proteínas
KW  - Ratones
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Enzyme Activation
KW  - Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiological Processes::Host-Pathogen Interactions
KW  - Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Immunity, Innate
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Peptide Mapping
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Protein Binding
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Double-Stranded
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Viral
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Ubiquitins::Small Ubiquitin-Related Modifier Proteins::SUMO-1 Protein
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, Protein
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Peptide Biosynthesis::Protein Biosynthesis::Protein Modification, Translational::Protein Processing,...
KW  - Medical Subject Headings::Organisms::Viruses::RNA Viruses::Mononegavirales::Rhabdoviridae::Vesiculovirus
KW  - Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiological Processes::Virus Physiological Processes::Virus Replication
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::eIF-2 Kinase
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::3T3 Cells
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Protein Multimerization
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
TI  - Activation of the double-stranded RNA-dependent protein kinase PKR by small ubiquitin-like modifier (SUMO).
TY  - research article
ER  -