TY - JOUR AU - Fernández-Santiago, Rubén AU - Martín-Flores, Núria AU - Antonelli, Francesca AU - Cerquera, Catalina AU - Moreno, Verónica AU - Bandres-Ciga, Sara AU - Manduchi, Elisabetta AU - Tolosa, Eduard AU - Singleton, Andrew B AU - Moore, Jason H AU - International Parkinson's Disease Genomics Consortium AU - Martí, María-Josep AU - Ezquerra, Mario AU - Malagelada, Cristina PY - 2019 DO - 10.1002/mds.27770 UR - http://hdl.handle.net/10668/14165 T2 - Movement disorders : official journal of the Movement Disorder Society AB - Single nucleotide polymorphisms (SNPs) in the α-synuclein (SNCA) gene are associated with differential risk and age at onset (AAO) of both idiopathic and Leucine-rich repeat kinase 2 (LRRK2)-associated Parkinson's disease (PD). Yet potential... LA - en KW - Parkinson's disease KW - SNP KW - age at onset KW - alpha-synuclein KW - epistasis KW - mTOR KW - Adult KW - Age of Onset KW - Aged KW - Aged, 80 and over KW - Chromosome Mapping KW - Cohort Studies KW - Epistasis, Genetic KW - Female KW - Genetic Predisposition to Disease KW - Genotype KW - Humans KW - Male KW - Middle Aged KW - Parkinson Disease KW - Polymorphism, Single Nucleotide KW - Risk Assessment KW - Signal Transduction KW - TOR Serine-Threonine Kinases KW - alpha-Synuclein TI - SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease. TY - research article VL - 34 ER -