RT Journal Article
T1 Focal therapy compared to radical prostatectomy for non-metastatic prostate cancer: a propensity score-matched study.
A1 Shah, Taimur T
A1 Reddy, Deepika
A1 Peters, Max
A1 Ball, Daniel
A1 Kim, Na Hyun
A1 Gomez, Enrique Gomez
A1 Miah, Saiful
A1 Evans, David Eldred
A1 Guillaumier, Stephanie
A1 van Rossum, Peter S N
A1 Van Son, Marieke J
A1 Hosking-Jervis, Feargus
A1 Dudderidge, Tim
A1 Hindley, Richard
A1 Emara, Amr
A1 McCracken, Stuart
A1 Greene, Damian
A1 Nigam, Raj
A1 McCartan, Neil
A1 Valerio, Massimo
A1 Minhas, Suks
A1 Afzal, Naveed
A1 Lewi, Henry
A1 Ogden, Chris
A1 Persad, Raj
A1 Virdi, Jaspal
A1 Moore, Caroline M
A1 Arya, Manit
A1 Emberton, Mark
A1 Ahmed, Hashim U
A1 Winkler, Mathias
K1 Outcomes research
K1 Prostate cancer
AB Focal therapy (FT) ablates areas of prostate cancer rather than treating the whole gland. We compared oncological outcomes of FT to radical prostatectomy (RP). Using prospective multicentre databases of 761 FT and 572 RP cases (November/2005-September/2018), patients with PSA  335 radical prostatectomy and 501 focal therapy patients were eligible for matching. For focal therapy, 420 had HIFU and 81 cryotherapy. Cryotherapy was used predominantly for anterior cancer. After matching, 246 RP and 246 FT cases were identified. For radical prostatectomy, mean (SD) age was 63.4 (5.6) years, median (IQR) PSA 7.9 g/ml (6-10) and median (IQR) follow-up 64 (30-89) months. For focal therapy, these were 63.3 (6.9) years, 7.9 ng/ml (5.5-10.6) and 49 [34-67] months, respectively. At 3, 5 and 8 years, FFS (95%CI) was 86% (81-91%), 82% (77-88%) and 79% (73-86%) for radical prostatectomy compared to 91% (87-95%), 86% (81-92%) and 83% (76-90%) following focal therapy (p = 0.12). In patients with non-metastatic low- intermediate prostate cancer, oncological outcomes over 8 years were similar between focal therapy and radical prostatectomy.
PB Nature Publishing Group
YR 2020
FD 2020-12-11
LK http://hdl.handle.net/10668/17059
UL http://hdl.handle.net/10668/17059
LA en
NO Shah TT, Reddy D, Peters M, Ball D, Kim NH, Gomez EG, et al. Focal therapy compared to radical prostatectomy for non-metastatic prostate cancer: a propensity score-matched study. Prostate Cancer Prostatic Dis. 2021 Jun;24(2):567-574.
DS RISalud
RD Apr 10, 2025