RT Journal Article
T1 Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function.
A1 Leon, Silvia
A1 Fernandois, Daniela
A1 Sull, Alexandra
A1 Sull, Judith
A1 Calder, Michele
A1 Hayashi, Kanako
A1 Bhattacharya, Moshmi
A1 Power, Stephen
A1 Vilos, George A
A1 Vilos, Angelos G
A1 Tena-Sempere, Manuel
A1 Babwah, Andy V
K1 Developmental biology
K1 Endocrinology
AB Uterine growth and endometrial gland formation (adenogenesis) and function, are essential for fertility and are controlled by estrogens and other regulators, whose nature and physiological relevance are yet to be elucidated. Kisspeptin, which signals via Kiss1r, is essential for fertility, primarily through its central control of the hypothalamic-pituitary-ovarian axis, but also likely through peripheral actions. Using genetically modified mice, we addressed the contributions of central and peripheral kisspeptin signaling in regulating uterine growth and adenogenesis. Global ablation of Kiss1 or Kiss1r dramatically suppressed uterine growth and almost fully prevented adenogenesis. However, while uterine growth was fully rescued by E2 treatment of Kiss1(-/-) mice and by genetic restoration of kisspeptin signaling in GnRH neurons in Kiss1r(-/-) mice, functional adenogenesis was only marginally restored. Thus, while uterine growth is largely dependent on ovarian E2-output via central kisspeptin signaling, peripheral kisspeptin signaling is indispensable for endometrial adenogenesis and function, essential aspects of reproductive competence.
PB Nature Publishing Group
YR 2016
FD 2016-06-10
LK http://hdl.handle.net/10668/10226
UL http://hdl.handle.net/10668/10226
LA en
NO León S, Fernandois D, Sull A, Sull J, Calder M, Hayashi K, et al. Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function. Sci Rep. 2016 Jul 1;6:29073.
DS RISalud
RD Apr 17, 2025