RT Journal Article T1 Consumption of Ultra-Processed Food and Drinks and Chronic Lymphocytic Leukemia in the MCC-Spain Study. A1 Solans, Marta A1 Fernández-Barrés, Sílvia A1 Romaguera, Dora A1 Benavente, Yolanda A1 Marcos-Gragera, Rafael A1 Gracia-Lavedan, Esther A1 Costas, Laura A1 Robles, Claudia A1 Gonzalez-Barca, Eva A1 de la Banda, Esmeralda A1 Alonso, Esther A1 Aymerich, Marta A1 Campo, Elias A1 Llorca, Javier A1 Fernández-Tardón, Guillermo A1 Olmedo-Requena, Rocío A1 Gimeno, Eva A1 Castaño-Vinyals, Gemma A1 Aragonés, Nuria A1 Kogevinas, Manolis A1 Pollán, Marina A1 de Sanjose, Silvia A1 Amiano, Pilar A1 Casabonne, Delphine K1 NOVA classification K1 cancer K1 case-control study K1 chronic lymphocytic leukemia K1 ultra-processed food AB Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. Its etiology is largely unknown but increasing incidence rates observed worldwide suggest that lifestyle and environmental factors such as diet might play a role in the development of CLL. Hence, we hypothesized that the consumption of ultra-processed food and drinks (UPF) might be associated with CLL. Data from a Spanish population-based case-control study (MCC-Spain study) including 230 CLL cases (recruited within three years of diagnosis) and 1634 population-based controls were used. The usual diet during the previous year was collected through a validated food frequency questionnaire and food and drink consumption was categorized using the NOVA classification scheme. Logistic regression models adjusted for potential confounders were used. Overall, no association was reported between the consumption of UPF and CLL cases (OR per each 10% increase of the relative contribution of UPF to total dietary intake = 1.09 (95% CI: 0.94; 1.25)), independently of the Rai stage at diagnosis. However, when analyses were restricted to cases diagnosed within YR 2021 FD 2021-05-20 LK http://hdl.handle.net/10668/17877 UL http://hdl.handle.net/10668/17877 LA en DS RISalud RD Apr 12, 2025