RT Generic
T1 Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216
A1 Gopcevic, Kristina R.
A1 Gkaliagkousi, Eugenia
A1 Nemcsik, Janos
A1 Acet, Omur
A1 Bernal-Lopez, M. Rosa
A1 Bruno, Rosa M.
A1 Climie, Rachel E.
A1 Fountoulakis, Nikolaos
A1 Fraenkel, Emil
A1 Lazaridis, Antonios
A1 Navickas, Petras
A1 Rochfort, Keith D.
A1 Satrauskiene, Agne
A1 Zupkauskiene, Jurate
A1 Terentes-Printzios, Dimitrios
K1 vascular aging
K1 circulating biomarkers
K1 oxidative stress
K1 inflammation
K1 cellular matrix
K1 epigenetics
K1 C-reactive protein
K1 Leukocyte telomere length
K1 Growth-differentiation factor-15
K1 Matrix metalloproteinases mmps
K1 Coronary-heart-disease
K1 Cardiovascular-disease
K1 Arterial stiffness
K1 Oxidative stress
K1 All-cause
K1 Endothelial-cells
AB Impairment of the arteries is a product of sustained exposure to various deleterious factors and progresses with time; a phenomenon inherent to vascular aging. Oxidative stress, inflammation, the accumulation of harmful agents in high cardiovascular risk conditions, changes to the extracellular matrix, and/or alterations of the epigenetic modification of molecules, are all vital pathophysiological processes proven to contribute to vascular aging, and also lead to changes in levels of associated circulating molecules. Many of these molecules are consequently recognized as markers of vascular impairment and accelerated vascular aging in clinical and research settings, however, for these molecules to be classified as biomarkers of vascular aging, further criteria must be met. In this paper, we conducted a scoping literature review identifying thirty of the most important, and eight less important, biomarkers of vascular aging. Herein, we overview a selection of the most important molecules connected with the above-mentioned pathological conditions and study their usefulness as circulating biomarkers of vascular aging.
PB Frontiers media sa
YR 2021
FD 2021-12-14
LK https://hdl.handle.net/10668/24490
UL https://hdl.handle.net/10668/24490
LA en
DS RISalud
RD Apr 5, 2025