RT Journal Article
T1 Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring
A1 Mustieles, Vicente
A1 D'Cruz, Shereen Cynthia
A1 Couderq, Stephan
A1 Rodríguez-Carrillo, Andrea
A1 Fini, Jean-Baptiste
A1 Hofer, Tim
A1 Steffensen, Inger-Lise
A1 Dirven, Hubert
A1 Barouki, Robert
A1 Olea, Nicolás
A1 Fernández, Mariana F.
A1 David, Arthur
K1 Bisphenol A
K1 Bisphenol analogues
K1 Human biomonitoring
K1 Effect biomarker
K1 Adverse outcome pathway
K1 Fenoles
K1 Monitoreo Biológico
K1 Humanos
K1 Biomarcadores
K1 Rutas de resultados adversos
AB Human biomonitoring (HBM) studies have demonstrated widespread and daily exposure to bisphenol A (BPA). Moreover, BPA structural analogues (e.g. BPS, BPF, BPAF), used as BPA replacements, are being increasingly detected in human biological matrices. BPA and some of its analogues are classified as endocrine disruptors suspected of contributing to adverse health outcomes such as altered reproduction and neurodevelopment, obesity, and metabolic disorders among other developmental and chronic impairments. One of the aims of the H2020 European Human Biomonitoring Initiative (HBM4EU) is the implementation of effect biomarkers at large scales in future HBM studies in a systematic and standardized way, in order to complement exposure data with mechanistically-based biomarkers of early adverse effects. This review aimed to identify and prioritize existing biomarkers of effect for BPA, as well as to provide relevant mechanistic and adverse outcome pathway (AOP) information in order to cover knowledge gaps and better interpret effect biomarker data. A comprehensive literature search was performed in PubMed to identify all the epidemiologic studies published in the last 10 years addressing the potential relationship between bisphenols exposure and alterations in biological parameters. A total of 5716 references were screened, out of which, 119 full-text articles were analyzed and tabulated in detail. This work provides first an overview of all epigenetics, gene transcription, oxidative stress, reproductive, glucocorticoid and thyroid hormones, metabolic and allergy/immune biomarkers previously studied. Then, promising effect biomarkers related to altered neurodevelopmental and reproductive outcomes including brain-derived neurotrophic factor (BDNF), kisspeptin (KiSS), and gene expression of nuclear receptors are prioritized, providing mechanistic insights based on in vitro, animal studies and AOP information. Finally, the potential of omics technologies for biomarker discovery and its implications for risk assessment are discussed. To the best of our knowledge, this is the first effort to comprehensively identify bisphenol-related biomarkers of effect for HBM purposes.
PB Elsevier
SN 0160-4120
YR 2020
FD 2020-08-28
LK http://hdl.handle.net/10668/3617
UL http://hdl.handle.net/10668/3617
LA en
NO Mustieles V, D'Cruz SC, Couderq S, Rodríguez-Carrillo A, Fini JB, Hofer T, et al. Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring. Environ Int. 2020 Nov;144:105811
DS RISalud
RD Apr 10, 2025