RT Journal Article
T1 Identification of patients at risk of non-adherence to oral antirheumatic drugs in rheumatoid arthritis using the Compliance Questionnaire in Rheumatology: an ARCO sub-study.
A1 Marras, Carlos
A1 Monteagudo, Indalecio
A1 Salvador, Georgina
A1 de Toro, Francisco J
A1 Escudero, Alejandro
A1 Alegre-Sancho, Juan J
A1 Raya, Enrique
A1 Ortiz, Ana
A1 Carmona, Loreto
A1 Mestre, Yvonne
A1 Cea-Calvo, Luis
A1 Calvo-Alén, Jaime
K1 Adherence
K1 Non-adherence
K1 Oral medication
K1 Questionnaire
K1 Rheumatoid arthritis
AB The ARCO study (Study on Adherence of Rheumatoid Arthritis patients to SubCutaneous and Oral Drugs), a multicenter, non-interventional retrospective study, was primarily designed to assess the percentage of patients [aged ≥18 years with an established rheumatoid arthritis (RA) diagnosis] with non-adherence to prescribed subcutaneous biologicals. This paper reports data for the secondary objective from a subset of patients, namely to evaluate non-adherence to prescribed oral antirheumatic drugs in RA patients in Spain using the validated Compliance Questionnaire Rheumatology (CQR). Patients also completed the Morisky-Green Medication Adherence Questionnaire, Beliefs about Medicines Questionnaire, and a questionnaire (developed and validated in Spain) on patient satisfaction with RA treatment and preferences. A total of 271 patients (76.7% females; mean age 55.6 years) were being treated with oral drugs for RA, of which 234 completed the CQR questionnaire. Non-adherence was reported in 49/234 (20.9%) patients. The proportion of non-adherence in younger patients (aged ≤48 years; 37.5%) was double that recorded in patients aged >48 years (p = 0.006). Patients with a perception of lower efficacy also had a higher risk of non-adherence (p = 0.012). Multivariable analysis showed that younger age and male gender were independently associated with risk of non-adherence. There was only slight agreement between the CQR and Morisky-Green assessment tools (kappa coefficient = 0.186), possibly reflecting the fact that both questionnaires measure slightly different aspects of medication adherence. In conclusion, one out of five RA patients was identified as at risk for non-adherence with the CQR, and this was more frequent in younger patients and in males.
YR 2017
FD 2017-05-17
LK http://hdl.handle.net/10668/11204
UL http://hdl.handle.net/10668/11204
LA en
DS RISalud
RD Apr 8, 2025