RT Journal Article
T1 Early infection is an independent risk factor for increased mortality in patients with culture-confirmed infected pancreatic necrosis.
A1 Moran, Robert A
A1 Halloran, Christopher
A1 Guo, Qiang
A1 Umapathy, Chandra
A1 Jalaly, Niloofar Y
A1 Jain, Saransh
A1 Cowzer, Darren
A1 Cuadrado Robles, Enrique Perez
A1 Quesada-Vázquez, Noé
A1 Szentesi, Andrea
A1 Papp, Mária
A1 Chua, Tiffany
A1 Márta, Katalin
A1 Sampath, Kartik
A1 Jin, David X
A1 Sahebally, Shaheel Mohammad
A1 Kuschnereit, Tobias Philipp
A1 Khashab, Mouen A
A1 Rock, Clare
A1 Darvasi, Erika
A1 Saunders, Rebecca
A1 García-Rayado, Guillermo
A1 Torrijos, Yolanda Sánchez
A1 Coady, Laoise
A1 Papachristou, Georgios I
A1 Mayerle, Julia
A1 Geoghegan, Justin
A1 Banks, Peter A
A1 Gardner, Timothy B
A1 Szabó, Anikó Nóra
A1 Stevens, Tyler
A1 Tornai, Tamás
A1 Tóth, Emese
A1 McEntee, Gerry
A1 Enrique de-Madaria, 
A1 Garg, Pramod K
A1 Hegyi, Péter
A1 Yadav, Dhiraj
A1 Hu, Weiming
A1 Neoptolemos, John
A1 Singh, Vikesh K
K1 Infected pancreatic necrosis
K1 Minimally invasive surgery
K1 Mortality
K1 Necrosectomy
K1 Necrotizing pancreatitis
K1 Pancreatic necrosis
K1 Surgery
AB Mortality in infected pancreatic necrosis (IPN) is dynamic over the course of the disease, with type and timing of interventions as well as persistent organ failure being key determinants. The timing of infection onset and how it pertains to mortality is not well defined. To determine the association between mortality and the development of early IPN. International multicenter retrospective cohort study of patients with IPN, confirmed by a positive microbial culture from (peri) pancreatic collections. The association between timing of infection onset, timing of interventions and mortality were assessed using Cox regression analyses. A total of 743 patients from 19 centers across 3 continents with culture-confirmed IPN from 2000 to 2016 were evaluated, mortality rate was 20.9% (155/734). Early infection was associated with a higher mortality, when early infection occurred within the first 4 weeks from presentation with acute pancreatitis. After adjusting for comorbidity, advanced age, organ failure, enteral nutrition and parenteral nutrition, early infection (≤4 weeks) and early open surgery (≤4 weeks) were associated with increased mortality [HR: 2.45 (95% CI: 1.63-3.67), p  0.05). Early infection was associated with increased mortality, independent of interventions. Early surgery remains a strong predictor of excess mortality.
YR 2021
FD 2021-11-09
LK http://hdl.handle.net/10668/22466
UL http://hdl.handle.net/10668/22466
LA en
DS RISalud
RD Apr 6, 2025