RT Journal Article
T1 Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape
A1 Salguero-Aranda, Carmen
A1 Amaral, Ana Teresa
A1 Olmedo-Pelayo, Joaquín
A1 Diaz-Martin, Juan
A1 de Álava, Enrique
K1 Sarcoma
K1 Ewing sarcoma
K1 GF
K1 Extracellular vesicles
K1 Circulating tumor DNA/RNA
K1 DNA repair
K1 Breakthrough technologies
K1 Mutations
K1 Sarcoma de Ewing
K1 Fusión génica
K1 Vesículas extracelulares
K1 ADN tumoral circulante
K1 Reparación del ADN
K1 Mutación
K1 Secuenciación de nucleótidos de alto rendimiento
AB Ewing sarcoma is a highly aggressive round cell mesenchymal neoplasm, most often occurring in children and young adults. At the molecular level, it is characterized by the presence of recurrent chromosomal translocations. In the last years, next-generation technologies have contributed to a more accurate diagnosis and a refined classification. Moreover, the application of these novel technologies has highlighted the relevance of intertumoral and intratumoral molecular heterogeneity and secondary genetic alterations. Furthermore, they have shown evidence that genomic features can change as the tumor disseminates and are influenced by treatment as well. Similarly, next-generation technologies applied to liquid biopsies will significantly impact patient management by allowing the early detection of relapse and monitoring response to treatment. Finally, the use of these novel technologies has provided data of great value in order to discover new druggable pathways. Thus, this review provides concise updates on the latest progress of these breakthrough technologies, underscoring their importance in the generation of key knowledge, prognosis, and potential treatment of Ewing Sarcoma.
PB MDPI
YR 2020
FD 2020-03-26
LK http://hdl.handle.net/10668/3811
UL http://hdl.handle.net/10668/3811
LA en
NO Salguero-Aranda C, Amaral AT, Olmedo-Pelayo J, Diaz-Martin J, de Álava E. Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape. Cells. 2020 Mar 26;9(4):804
DS RISalud
RD Apr 10, 2025