RT Journal Article
T1 Vascular endothelial growth factor haplotypes are associated with severe ischaemic complications in giant cell arteritis regardless of the disease phenotype.
A1 Prieto-Peña, Diana
A1 Remuzgo-Martínez, Sara
A1 Genre, Fernanda
A1 Ocejo-Vinyals, Javier Gonzalo
A1 Atienza-Mateo, Belén
A1 Muñoz-Jimenez, Alejandro
A1 Ortiz-Sanjuán, Francisco
A1 Romero-Yuste, Susana
A1 Moriano, Clara
A1 Galíndez-Agirregoikoa, Eva
A1 Calvo, Itziar
A1 Ortego-Centeno, Norberto
A1 Álvarez-Rivas, Noelia
A1 Miranda-Filloy, Jose A
A1 Llorente, Irene
A1 Blanco, Ricardo
A1 Gualillo, Oreste
A1 Martín, Javier
A1 Márquez, Ana
A1 Castañeda, Santos
A1 Ferraz-Amaro, Iván
A1 López-Mejías, Raquel
A1 González-Gay, Miguel A
AB To determine whether functional vascular endothelial growth factor (VEGF) polymorphisms influence the expression of the clinical phenotype of giant cell arteritis (GCA). We also evaluated whether VEGF polymorphism is associated with the development of severe ischaemic manifestations in patients with GCA regardless of the clinical phenotype, classic cranial GCA or predominantly extracranial GCA large vessel vasculitis (LVV). VEGF rs833061 T/C, rs2010963 G/C and rs3025039 C/T polymorphisms were genotyped in 185 patients with biopsy-proven cranial GCA, 105 with extracranial LVV-GCA and 490 healthy controls. Allelic combinations (haplotypes) of VEGF were carried out. Comparisons were performed between patients with GCA and healthy controls as well as between patients with GCA stratified according to the clinical phenotype and the presence of severe ischaemic manifestations. No significant differences in genotype, allele, and haplotype frequencies of VEGF were found between patients with GCA and healthy controls as well as between GCA patients with the classic cranial pattern and the extracranial LVV-GCA pattern of the disease. However, the VEGF CGC haplotype (OR= 1.63 [1.05-2.53]) and the CGT haplotype (OR= 2.55 [1.10-5.91]) were significantly more frequent in GCA patients with severe ischaemic complications compared to those patients without these complications. VEGF haplotypes seem to play a role in the development of severe ischaemic manifestations in GCA patients, regardless of the clinical phenotype of expression of the disease.
SN 0392-856X
YR 2022
FD 2022-03-23
LK http://hdl.handle.net/10668/21837
UL http://hdl.handle.net/10668/21837
LA en
DS RISalud
RD Apr 5, 2025