RT Journal Article
T1 Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper.
A1 Kowalski, Marek L
A1 Agache, Ioana
A1 Bavbek, Sevim
A1 Bakirtas, Arzu
A1 Blanca, Miguel
A1 Bochenek, Grazyna
A1 Bonini, Matteo
A1 Heffler, Enrico
A1 Klimek, Ludger
A1 Laidlaw, Tanya M
A1 Mullol, Joaquim
A1 Nizankowska-Mogilnicka, Ewa
A1 Park, Hae-Sim
A1 Sanak, Marek
A1 Sanchez-Borges, Mario
A1 Sanchez-Garcia, Silvia
A1 Scadding, Glenis
A1 Taniguchi, Masami
A1 Torres, Maria J
A1 White, Andrew A
A1 Wardzynska, Aleksandra
K1 AERD
K1 ENT (rhinitis, sinusitis, nasal polyps…)
K1 Asthma
K1 Asthma treatment
K1 Drug allergy
K1 Sinusitis
AB NSAID-exacerbated respiratory disease (N-ERD) is a chronic eosinophilic, inflammatory disorder of the respiratory tract occurring in patients with asthma and/or chronic rhinosinusitis with nasal polyps (CRSwNP), symptoms of which are exacerbated by NSAIDs, including aspirin. Despite some progress in understanding of the pathophysiology of the syndrome, which affects 1/10 of patients with asthma and rhinosinusitis, it remains a diagnostic and therapeutic challenge. In order to provide evidence-based recommendations for the diagnosis and management of N-ERD, a panel of international experts was called by the EAACI Asthma Section. The document summarizes current knowledge on the pathophysiology and clinical presentation of N-ERD pointing at significant heterogeneity of this syndrome. Critically evaluating the usefulness of diagnostic tools available, the paper offers practical algorithm for the diagnosis of N-ERD. Recommendations for the most effective management of a patient with N-ERD stressing the potential high morbidity and severity of the underlying asthma and rhinosinusitis are discussed and proposed. Newly described sub-phenotypes and emerging sub-endotypes of N-ERD are potentially relevant for new and more specific (eg, biological) treatment modalities. Finally, the document defines major gaps in our knowledge on N-ERD and unmet needs, which should be addressed in the future.
PB John Wiley and Sons
YR 2019
FD 2019-01-30
LK http://hdl.handle.net/10668/12946
UL http://hdl.handle.net/10668/12946
LA en
NO Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, et al. Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper. Allergy. 2019 Jan;74(1):28-39
DS RISalud
RD Apr 11, 2025