%0 Journal Article
%A Kowalski, Marek L
%A Agache, Ioana
%A Bavbek, Sevim
%A Bakirtas, Arzu
%A Blanca, Miguel
%A Bochenek, Grazyna
%A Bonini, Matteo
%A Heffler, Enrico
%A Klimek, Ludger
%A Laidlaw, Tanya M
%A Mullol, Joaquim
%A Nizankowska-Mogilnicka, Ewa
%A Park, Hae-Sim
%A Sanak, Marek
%A Sanchez-Borges, Mario
%A Sanchez-Garcia, Silvia
%A Scadding, Glenis
%A Taniguchi, Masami
%A Torres, Maria J
%A White, Andrew A
%A Wardzynska, Aleksandra
%T Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper.
%D 2019
%U http://hdl.handle.net/10668/12946
%X NSAID-exacerbated respiratory disease (N-ERD) is a chronic eosinophilic, inflammatory disorder of the respiratory tract occurring in patients with asthma and/or chronic rhinosinusitis with nasal polyps (CRSwNP), symptoms of which are exacerbated by NSAIDs, including aspirin. Despite some progress in understanding of the pathophysiology of the syndrome, which affects 1/10 of patients with asthma and rhinosinusitis, it remains a diagnostic and therapeutic challenge. In order to provide evidence-based recommendations for the diagnosis and management of N-ERD, a panel of international experts was called by the EAACI Asthma Section. The document summarizes current knowledge on the pathophysiology and clinical presentation of N-ERD pointing at significant heterogeneity of this syndrome. Critically evaluating the usefulness of diagnostic tools available, the paper offers practical algorithm for the diagnosis of N-ERD. Recommendations for the most effective management of a patient with N-ERD stressing the potential high morbidity and severity of the underlying asthma and rhinosinusitis are discussed and proposed. Newly described sub-phenotypes and emerging sub-endotypes of N-ERD are potentially relevant for new and more specific (eg, biological) treatment modalities. Finally, the document defines major gaps in our knowledge on N-ERD and unmet needs, which should be addressed in the future.
%K AERD
%K ENT (rhinitis, sinusitis, nasal polyps…)
%K Asthma
%K Asthma treatment
%K Drug allergy
%K Sinusitis
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