RT Conference Proceedings
T1 Chromosome and abnormalities are associated with an even worse outcome and karyotype complexity in patiens with chronic lymphocytic leukemia and TP53 A
A1 Blanco, A
A1 Puiggros, A
A1 Baliakas, P
A1 Athanasiadou, A
A1 García-Malo, MD
A1 Collado, R
A1 Xochelli, A
A1 Rodríguez-Rivera, M
A1 Ortega, M
A1 Calasanz, MJ
A1 Luño, E
A1 Vargas, MT
A1 Grau, J
A1 Martínez-Laperche, C
A1 Valiente, A
A1 Papaioannou, G
A1 Cervera, J
A1 Anagnostopoulos, A
A1 Piñán, MA
A1 Stalika, E
A1 Hernández-Rivas, JM
A1 Batlle, A
A1 Salido, M
A1 Ortuño, F
A1 Melero, c
A1 Robles, D
A1 Ferrer, A
A1 Ivars, D
A1 Rodríguez, A
A1 González, M
A1 Bosch, F
A1 Abrisqueta, P
A1 Stamatopoulos, K
A1 Espinet, B
K1 Cromosomas humanos par 8
K1 Citogenética
K1 Leucemia linfoide
K1 Esperanza de vida
K1 Eliminación de secuencia
AB TP53 aberrations (deletions and/or mutations, TP53ab) in chronic lymphocytic leukemia (CLL) are associated with dismal clinical outcome and reduced life expectancy. However, mounting evidence suggests that within cases carrying TP53ab other cytogenetic features may also influence the clinical outcome. Alterations in chromosome 8, in particular 8p losses (affecting several regions, from 8p12 to 8p23) and 8q gains (usually involving 8q24, where MYC is located), are enriched in TP53ab patients and have been proposed as features with potential prognostic value within this aggressive group.
PB Ferrata Storti Foundation
SN 0390-6078
YR 2016
FD 2016-06-09
LK http://hdl.handle.net/10668/2539
UL http://hdl.handle.net/10668/2539
LA en
NO Blanco G, Puiggros A, Baliakas P, Athanasiadou A, García-Malo MD, Collado R, el al. Chromosome and abnormalities are associated with an even worse outcome and karyotype complexity in patiens with chronic lymphocytic leukemia and TP53 A. HAEMATOLOGICA. 2016, Vol. 101, (S1) pp. 229-230
DS RISalud
RD Apr 11, 2025