RT Journal Article
T1 Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study.
A1 Forouhi, Nita G
A1 Imamura, Fumiaki
A1 Sharp, Stephen J
A1 Koulman, Albert
A1 Schulze, Matthias B
A1 Zheng, Jusheng
A1 Ye, Zheng
A1 Sluijs, Ivonne
A1 Guevara, Marcela
A1 Huerta, José María
A1 Kröger, Janine
A1 Wang, Laura Yun
A1 Summerhill, Keith
A1 Griffin, Julian L
A1 Feskens, Edith J M
A1 Affret, Aurélie
A1 Amiano, Pilar
A1 Boeing, Heiner
A1 Dow, Courtney
A1 Fagherazzi, Guy
A1 Franks, Paul W
A1 Gonzalez, Carlos
A1 Kaaks, Rudolf
A1 Key, Timothy J
A1 Khaw, Kay Tee
A1 Kühn, Tilman
A1 Mortensen, Lotte Maxild
A1 Nilsson, Peter M
A1 Overvad, Kim
A1 Pala, Valeria
A1 Palli, Domenico
A1 Panico, Salvatore
A1 Quirós, J Ramón
A1 Rodriguez-Barranco, Miguel
A1 Rolandsson, Olov
A1 Sacerdote, Carlotta
A1 Scalbert, Augustin
A1 Slimani, Nadia
A1 Spijkerman, Annemieke M W
A1 Tjonneland, Anne
A1 Tormo, Maria-Jose
A1 Tumino, Rosario
A1 van der A, Daphne L
A1 van der Schouw, Yvonne T
A1 Langenberg, Claudia
A1 Riboli, Elio
A1 Wareham, Nicholas J
K1 Diabetes Mellitus Tipo 2
K1 Ácidos Grasos Omega-6
K1 Ácidos Grasos Insaturados
K1 Fosfolípidos
K1 Plasma
K1 Ácido 8,11,14-eicosanoico
K1 Ácido araquidónico
K1 Cromatografía de gases
K1 Dieta
K1 Ácidos docosahexaenoicos
K1 Ácido eicosapentaenoico
K1 Europa
K1 Ácidos grasos omega 3
K1 Ácido linoleico
K1 Estudios prospectivos
AB BACKGROUNDWhether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations.METHODS AND FINDINGSPlasma phospholipid PUFAs were measured by gas chromatography among 12,132 incident T2D cases and 15,919 subcohort participants in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study across eight European countries. Country-specific hazard ratios (HRs) were estimated using Prentice-weighted Cox regression and pooled by random-effects meta-analysis. We also systematically reviewed published prospective studies on circulating PUFAs and T2D risk and pooled the quantitative evidence for comparison with results from EPIC-InterAct. In EPIC-InterAct, among long-chain n-3 PUFAs, α-linolenic acid (ALA) was inversely associated with T2D (HR per standard deviation [SD] 0.93; 95% CI 0.88-0.98), but eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were not significantly associated. Among n-6 PUFAs, linoleic acid (LA) (0.80; 95% CI 0.77-0.83) and eicosadienoic acid (EDA) (0.89; 95% CI 0.85-0.94) were inversely related, and arachidonic acid (AA) was not significantly associated, while significant positive associations were observed with γ-linolenic acid (GLA), dihomo-GLA, docosatetraenoic acid (DTA), and docosapentaenoic acid (n6-DPA), with HRs between 1.13 to 1.46 per SD. These findings from EPIC-InterAct were broadly similar to comparative findings from summary estimates from up to nine studies including between 71 to 2,499 T2D cases. Limitations included potential residual confounding and the inability to distinguish between dietary and metabolic influences on plasma phospholipid PUFAs.CONCLUSIONSThese large-scale findings suggest an important inverse association of circulating plant-origin n-3 PUFA (ALA) but no convincing association of marine-derived n3 PUFAs (EPA and DHA) with T2D. Moreover, they highlight that the most abundant n6-PUFA (LA) is inversely associated with T2D. The detection of associations with previously less well-investigated PUFAs points to the importance of considering individual fatty acids rather than focusing on fatty acid class.
PB Public Library of Science
SN 1549-1277
YR 2016
FD 2016-07-19
LK http://hdl.handle.net/10668/2395
UL http://hdl.handle.net/10668/2395
LA en
NO Forouhi NG, Imamura F, Sharp SJ, Koulman A, Schulze MB, Zheng J, et al. Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study. PLoS Med. 2016; 13(7): e1002094
NO Journal Article;
DS RISalud
RD Apr 13, 2025