TY  - JOUR
AU  - Dichiara, Maria
AU  - Artacho-Cordón, Antonia
AU  - Turnaturi, Rita
AU  - Santos-Caballero, Miriam
AU  - González-Cano, Rafael
AU  - Pasquinucci, Lorella
AU  - Barbaraci, Carla
AU  - Rodríguez-Gómez, Isabel
AU  - Gómez-Guzmán, Manuel
AU  - Marrazzo, Agostino
AU  - Cobos, Enrique J
AU  - Amata, Emanuele
PY  - 2022
DO  - 10.1016/j.ejmech.2021.114091
UR  - http://hdl.handle.net/10668/22186
T2  - European journal of medicinal chemistry
AB  - The development of σ1 receptor antagonists hybridized with a H2S-donor is here reported. We aimed to obtain improved analgesic effects when compared to σ1 receptor antagonists or H2S-donors alone. In an in vivo model of sensory hypersensitivity,...
LA  - en
KW  - Analgesia
KW  - Antagonist
KW  - Dual ligands
KW  - Hydrogen sulfide donor
KW  - Sigma-1 receptor
KW  - Animals
KW  - Guinea Pigs
KW  - Hydrogen
KW  - Hydrogen Sulfide
KW  - Ligands
KW  - Male
KW  - Morpholines
KW  - Pain
KW  - Piperazines
KW  - Rats, Sprague-Dawley
KW  - Receptors, sigma
TI  - Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.
TY  - research article
VL  - 230
ER  -