RT Journal Article
T1 TRPs in Pain Sensation.
A1 Jardín, Isaac
A1 López, José J
A1 Diez, Raquel
A1 Sánchez-Collado, José
A1 Cantonero, Carlos
A1 Albarrán, Letizia
A1 Woodard, Geoffrey E
A1 Redondo, Pedro C
A1 Salido, Ginés M
A1 Smani, Tarik
A1 Rosado, Juan A
K1 TRPA1
K1 TRPV1
K1 TRPs
K1 calcium entry
K1 noxious sensation
AB According to the International Association for the Study of Pain (IASP) pain is characterized as an "unpleasant sensory and emotional experience associated with actual or potential tissue damage". The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and pathophysiological processes, pain among them. TRP channel might be constituted by similar or different TRP subunits, which will result in the formation of homomeric or heteromeric channels with distinct properties and functions. In this review we will discuss about the function of TRPs in pain, focusing on TRP channles that participate in the transduction of noxious sensation, especially TRPV1 and TRPA1, their expression in nociceptors and their sensitivity to a large number of physical and chemical stimuli.
SN 1664-042X
YR 2017
FD 2017-06-09
LK https://hdl.handle.net/10668/26989
UL https://hdl.handle.net/10668/26989
LA en
DS RISalud
RD Apr 17, 2025