RT Generic
T1 Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results
A1 Mut-Salud, Nuria
A1 Juan Alvarez, Pablo
A1 Manuel Garrido, Jose
A1 Carrasco, Esther
A1 Aranega, Antonia
A1 Rodriguez-Serrano, Fernando
K1 Breast-cancer cells
K1 Green tea catechins
K1 Cisplatin-induced nephrotoxicity
K1 Reduces oxidative stress
K1 Quality-of-life
K1 Prostate-cancer
K1 N-acetylcysteine
K1 Free-radicals
K1 In-vitro
K1 Dietary polyphenols
AB The role of the induction of oxidative stress as the mechanism of action of many antitumor drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may be conditioned by the antioxidants present in our own body, which can be synthesized de novo (endogenous) or incorporated through the diet and nutritional supplements (exogenous). In this paper, we have reviewed different aspects of antioxidants, including their classification, natural sources, importance in diet, consumption of nutritional supplements, and the impact of antioxidants on health. Moreover, we have focused especially on the study of the interaction between antioxidants and antitumor therapy, considering both radiotherapy and chemotherapy. In this regard, we found that the convenience of administration of antioxidants during cancer treatment still remains a very controversial issue. In general terms, antioxidants could promote or suppress the effectiveness of antitumor treatment and even protect healthy tissues against damage induced by oxidative stress. The effects may depend on many factors discussed in the paper. These factors should be taken into consideration in order to achieve precise nutritional recommendations for patients. The evidence at the moment suggests that the supplementation or restriction of exogenous antioxidants during cancer treatment, as appropriate, could contribute to improving its efficiency.
PB Hindawi ltd
SN 1942-0900
YR 2016
FD 2016-01-01
LK http://hdl.handle.net/10668/19049
UL http://hdl.handle.net/10668/19049
LA en
DS RISalud
RD Apr 10, 2025