RT Journal Article
T1 Imaging findings of multisystem inflammatory syndrome in children associated with COVID-19.
A1 Caro-Domínguez, Pablo
A1 Navallas, María
A1 Riaza-Martin, Lucia
A1 Ghadimi Mahani, Maryam
A1 Ugas Charcape, Carlos F
A1 Valverde, Israel
A1 D'Arco, Felice
A1 Toso, Seema
A1 Shelmerdine, Susan Cheng
A1 van Schuppen, Joost
A1 Secinaro, Aurelio
A1 Gräfe, Daniel
A1 Camacho, Marisol
A1 Neth, Olaf
A1 Goo, Hyun Woo
A1 Kellenberger, Christian J
K1 COVID-19
K1 Children
K1 Coronavirus
K1 Imaging
K1 Multisystem inflammatory syndrome
K1 Radiology
AB A hyperinflammatory immune-mediated shock syndrome has been recognised in children exposed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). To describe typical imaging findings in children with multisystem inflammatory syndrome associated with COVID-19. During the first wave of the COVID-19 pandemic, imaging studies and clinical data from children treated for multisystem inflammatory syndrome were collected from multiple centres. Standardised case templates including demographic, biochemical and imaging information were completed by participating centres and reviewed by paediatric radiologists and paediatricians. We included 37 children (21 boys; median age 8.0 years). Polymerase chain reaction (PCR) testing was positive for SARS-CoV-2 in 15/37 (41%) children and immunoglobulins in 13/19 children (68%). Common clinical presentations were fever (100%), abdominal pain (68%), rash (54%), conjunctivitis (38%) and cough (32%). Thirty-three children (89%) showed laboratory or imaging findings of cardiac involvement. Thirty of the 37 children (81%) required admission to the intensive care unit, with good recovery in all cases. Chest radiographs demonstrated cardiomegaly in 54% and signs of pulmonary venous hypertension/congestion in 73%. The most common chest CT abnormalities were ground-glass and interstitial opacities (83%), airspace consolidation (58%), pleural effusion (58%) and bronchial wall thickening (42%). Echocardiography revealed impaired cardiac function in half of cases (51%) and coronary artery abnormalities in 14%. Cardiac MRI showed myocardial oedema in 58%, pericardial effusion in 42% and decreased left ventricular function in 25%. Twenty children required imaging for abdominal symptoms, the commonest abnormalities being free fluid (71%) and terminal ileum wall thickening (57%). Twelve children underwent brain imaging, showing abnormalities in two cases. Children with multisystem inflammatory syndrome showed pulmonary, cardiac, abdominal and brain imaging findings, reflecting the multisystem inflammatory disease. Awareness of the imaging features of this disease is important for early diagnosis and treatment.
YR 2021
FD 2021-04-27
LK http://hdl.handle.net/10668/17642
UL http://hdl.handle.net/10668/17642
LA en
DS RISalud
RD Apr 7, 2025