RT Journal Article
T1 Long-term outcome of patients after a single interruption of antiretroviral therapy: a cohort study.
A1 Machado, Carmen
A1 Ríos-Villegas, María José
A1 Gálvez-Acebal, Juan
A1 Domínguez-Castellano, Angel
A1 Fernández-Cuenca, Felipe
A1 Palomo, Virginia
A1 Muniain, Miguel Angel
A1 Rodríguez-Baño, Jesús
K1 HIV-1
K1 Antiretroviral therapy
K1 Treatment interruption
K1 Outcome
K1 Cohort study
K1 Fármacos anti-VIH
K1 Tratamiento antirretrovírico de gran actividad
K1 Pauta de administración medicamentosa
K1 Infecciones por VIH
K1 Estudios retrospectivos
K1 Resultado del tratamiento
AB BACKGROUNDTo describe the long term outcome of patients who interrupted highly active antiretroviral therapy (HAART) once, identify the variables associated with earlier need to re-start HAART, and the response when therapy was resumed. A retrospective observational cohort of 66 adult patients with HIV-1 infection who interrupted HAART with a CD4+cell count ≥ 350 cells/μL and undetectable viral load (VL) was performed. The pre-established CD4+ cell count for restarting therapy was 300cells/μL. Cox regression was used to analyse the variables associated with earlier HAART reinitiation.RESULTSThe median follow-up was 209 weeks (range, 64-395). Rates of HIV-related or possible HIV-related events were 0.37 (one case of acute retroviral syndrome) and 1.49 per 100 patient-years, respectively. Two patients died after re-starting therapy and having reached undetectable VL. Three patients suffered a sexually transmitted disease while off therapy. Fifty patients (76%) resumed therapy after a median of 97 weeks (range, 17-267). Age, a nadir of CD4+ <250 cells/μL, and a mean VL during interruption of >10,000 copies/ml were independent predictors for earlier re-start. The intention-to-treat success rate of the first HAART resumed regimen was 85.4%. There were no differences by regimen used, nor between regimens that were the same as or different from the one that had been interrupted.CONCLUSIONSOur data suggest highly active antiretroviral therapy may be interrupted in selected patients because in these patients, when the HAART is restarted, the viral and clinical response may be achieved.
PB BioMed Central
YR 2012
FD 2012-10-24
LK http://hdl.handle.net/10668/1571
UL http://hdl.handle.net/10668/1571
LA en
NO Machado C, Ríos-Villegas MJ, Gálvez-Acebal J, Domínguez-Castellano A, Fernández-Cuenca F, Palomo V, et al. Long-term outcome of patients after a single interruption of antiretroviral therapy: a cohort study. BMC Res Notes. 2012; 5:578
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 17, 2025