RT Journal Article
T1 Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people
A1 Herrero-Fernández, I.
A1 Rosado-Sánchez, I.
A1 Álvarez-Ríos, A. I.
A1 Galvá, M. I.
A1 De Luna-Romero, M.
A1 Sanbonmatsu-Gámez, S.
A1 Pérez-Ruiz, M.
A1 Navarro-Marí, J. M.
A1 Carrillo-Vico, A.
A1 Sánchez, B.
A1 Ramos, R.
A1 Cañizares, J.
A1 Leal, M.
A1 Pacheco, Y. M.
K1 Treg
K1 Ki 67
K1 Inflammation
K1 Thymic function
K1 TREC
K1 T-Lymphocytes, regulatory
K1 Antígeno Ki-67
K1 Inflamación
K1 Vacunas contra la influenza
K1 Influenza vaccines
AB Background: Seasonal influenza virus infection is a significant cause of morbimortality in the elderly. However, there is poor vaccine efficacy in this population due to immunosenescence. We aimed to explore several homeostatic parameters in the elderly that could impact influenza vaccine responsiveness.Methods: Subjects (> 60 years old) who were vaccinated against influenza virus were included, and the vaccine response was measured by a haemagglutination inhibition (HAI) test. At baseline, peripheral CD4 and CD8 T-cells were phenotypically characterized. Thymic function and the levels of different inflammation-related biomarkers, including Lipopolysaccharide Binding Protein (LBP) and anti-cytomegalovirus (CMV) IgG antibodies, were also measured.Results: Influenza vaccine non-responders showed a tendency of higher frequency of regulatory T-cells (Tregs) before vaccination than responders (1.49 [1.08-1.85] vs. 1.12 [0.94-1.63], respectively, p = 0.061), as well as higher expression of the proliferation marker Ki67 in Tregs and different CD4 and CD8 T-cell maturational subsets. The levels of inflammation-related biomarkers correlated with the frequencies of different proliferating T-cell subsets and with thymic function (e.g., thymic function with D-dimers, r = - 0.442, p = 0.001).Conclusions: Age-related homeostatic dysregulation involving the proliferation of CD4 and CD8 T-cell subsets, including Tregs, was related to a limited responsiveness to influenza vaccination and a higher inflammatory status in a cohort of elderly people.
PB BioMed Central Ltd.
YR 2019
FD 2019-07-05
LK http://hdl.handle.net/10668/3167
UL http://hdl.handle.net/10668/3167
LA en
NO Herrero-Fernández I, Rosado-Sánchez I, Álvarez-Ríos AI, Galvá MI, De Luna-Romero M, Sanbonmatsu-Gámez S,et al. Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people. Immun Ageing. 2019 Jul 5;16:14.
DS RISalud
RD Apr 19, 2025