RT Journal Article
T1 Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis: a cluster analysis in the worldwide ASAS-PerSpA study
A1 Lopez-Medina, Clementina
A1 Chevret, Sylvie
A1 Molto, Anna
A1 Sieper, Joachim
A1 Duruoz, Tuncay
A1 Kiltz, Uta
A1 Elzorkany, Bassel
A1 Hajjaj-Hassouni, Najia
A1 Burgos-Vargas, Ruben
A1 Maldonado-Cocco, Jose
A1 Ziade, Nelly
A1 Gavali, Meghna
A1 Navarro-Compan, Victoria
A1 Luo, Shue-Fen
A1 Biglia, Alessandro
A1 Tae-Jong, Kim
A1 Kishimoto, Mitsumasa
A1 Pimentel-Santos, Fernando M.
A1 Gu, Jieruo
A1 Muntean, Laura
A1 van Gaalen, Floris A.
A1 Geher, Pal
A1 Magrey, Marina
A1 Ibanez-Vodnizza, Sebastian E.
A1 Bautista-Molano, Wilson
A1 Maksymowych, Walter
A1 Machado, Pedro M.
A1 Landewe, Robert
A1 van der Heijde, Desiree
A1 Dougados, Maxime
K1 spondylitis
K1 ankylosing
K1 arthritis
K1 psoriatic
K1 arthritis
K1 Classification criteria
K1 Ankylosing-spondylitis
AB Objective To identify clusters of peripheral involvement according to the specific location of peripheral manifestations (ie, arthritis, enthesitis and dactylitis) in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), and to evaluate whether these clusters correspond with the clinical diagnosis of a rheumatologist. Methods Cross-sectional study with 24 participating countries. Consecutive patients diagnosed by their rheumatologist as PsA, axial SpA or peripheral SpA were enrolled. Four different cluster analyses were conducted: one using information on the specific location from all the peripheral manifestations, and a cluster analysis for each peripheral manifestation, separately. Multiple correspondence analyses and k-means clustering methods were used. Distribution of peripheral manifestations and clinical characteristics were compared across the different clusters. Results The different cluster analyses performed in the 4465 patients clearly distinguished a predominantly axial phenotype (cluster 1) and a predominantly peripheral phenotype (cluster 2). In the predominantly axial phenotype, hip involvement and lower limb large joint arthritis, heel enthesitis and lack of dactylitis were more prevalent. In the predominantly peripheral phenotype, different subgroups were distinguished based on the type and location of peripheral involvement: a predominantly involvement of upper versus lower limbs joints, a predominantly axial enthesitis versus peripheral enthesitis, and predominantly finger versus toe involvement in dactylitis. A poor agreement between the clusters and the rheumatologist's diagnosis as well as with the classification criteria was found. Conclusion These results suggest the presence of two main phenotypes (predominantly axial and predominantly peripheral) based on the presence and location of the peripheral manifestations.
PB Bmj publishing group
SN 2056-5933
YR 2021
FD 2021-11-01
LK https://hdl.handle.net/10668/25847
UL https://hdl.handle.net/10668/25847
LA en
DS RISalud
RD Apr 8, 2025