RT Journal Article
T1 Altered Expression of CD300a Inhibitory Receptor on CD4+ T Cells From Human Immunodeficiency Virus-1-Infected Patients: Association With Disease Progression Markers.
A1 Vitalle, Joana
A1 Terren, Iñigo
A1 Gamboa-Urquijo, Leire
A1 Orrantia, Ane
A1 Tarancon-Diez, Laura
A1 Genebat, Miguel
A1 Ruiz-Mateos, Ezequiel
A1 Leal, Manuel
A1 Garcia-Obregon, Susana
A1 Zenarruzabeitia, Olatz
A1 Borrego, Francisco
K1 CD300
K1 CD300a
K1 CD4 T cells
K1 PD1
K1 human immunodeficiency virus-1
AB The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule. Within human CD4+ T lymphocytes from healthy donors, the inhibitory receptor CD300a is differentially expressed among different T helper subsets. However, there are no data about the expression and regulation of CD300a receptor on CD4+ T cells from human immunodeficiency virus (HIV)-1-infected patients. The objective of this study was to investigate the expression of CD300a on CD4+ T cells from HIV-infected patients on suppressive combined antiretroviral therapy (cART) and cART naïve patients. Our results have demonstrated that the expression levels of this inhibitory receptor were higher on CD4+ T cells from HIV-1 infected subjects compared with healthy donors, and that cART did not reverse the altered expression of CD300a receptor in these patients. We have observed an increase of CD300a expression on both PD1+CD4+ and CD38+CD4+ T cells from HIV-1 infected people. Interestingly, a triple positive (CD300a+PD1+CD38+) subset was expanded in naïve HIV-1 infected patients, while it was very rare in healthy donors and patients on cART. Finally, we found a negative correlation of CD300a expression on CD4+ T lymphocytes and some markers associated with HIV-1 disease progression. Thus, our results show that HIV-1 infection has an impact in the regulation of CD300a inhibitory receptor expression levels, and further studies will shed light into the role of this cell surface receptor in the pathogenesis of HIV infection.
PB Frontiers Research Foundation
SN 1664-3224
YR 2018
FD 2018-07-23
LK http://hdl.handle.net/10668/12809
UL http://hdl.handle.net/10668/12809
LA en
NO Vitallé J, Terrén I, Gamboa-Urquijo L, Orrantia A, Tarancón-Díez L, Genebat M, et al. Altered Expression of CD300a Inhibitory Receptor on CD4+ T Cells From Human Immunodeficiency Virus-1-Infected Patients: Association With Disease Progression Markers. Front Immunol. 2018 Jul 23;9:1709.
DS RISalud
RD Apr 5, 2025