RT Journal Article
T1 Perinatal and childhood factors and risk of breast cancer subtypes in adulthood.
A1 Lope, Virginia
A1 García-Esquinas, Esther
A1 Pérez-Gómez, Beatriz
A1 Altzibar, Jone M
A1 Gracia-Lavedan, Esther
A1 Ederra, María
A1 Molina de la Torre, Antonio José
A1 LLorca, Francisco Javier
A1 Tardón, Adonina
A1 Moreno, Víctor
A1 Bayo, Juan
A1 Salas-Trejo, Dolores
A1 Marcos-Gragera, Rafael
A1 Pumarega, José
A1 Dierssen-Sotos, Trinidad
A1 Lera, Juan Pablo Barrio
A1 de Miguel Medina, M A Concepción
A1 Tusquets, Ignasi
A1 Amiano, Pilar
A1 Boldo, Elena
A1 Kogevinas, Manolis
A1 Aragonés, Nuria
A1 Castaño-Vinyals, Gemma
A1 Pollán, Marina
K1 Breast cancer subtypes
K1 Case-control study
K1 Childhood factors
K1 Childhood height
K1 Childhood weight
K1 Early life factors
K1 Hormone receptor
K1 Maternal age
K1 Perinatal factors
K1 Spain
AB Accumulated exposure to hormones and growth factors during early life may influence the future risk of breast cancer (BC). This study examines the influence of childhood-related, socio-demographic and anthropometric variables on BC risk, overall and by specific pathologic subtypes. This is a case-control study where 1539 histologically-confirmed BC cases (23-85 years) and 1621 population controls, frequency matched by age, were recruited in 10 Spanish provinces. Perinatal and childhood-related characteristics were directly surveyed by trained staff. The association with BC risk, globally and according to menopausal status and pathologic subtypes, was evaluated using logistic and multinomial regression models, adjusting for tumor specific risk factors. Birth characteristics were not related with BC risk. However, women with high socioeconomic level at birth presented a decreased BC risk (OR=0.45; 95% CI=0.29-0.70), while those whose mothers were aged over 39 years at their birth showed an almost significant excess risk of hormone receptor positive tumors (HR+) (OR=1.35; 95% CI=0.99-1.84). Women who were taller than their girl mates before puberty showed increased postmenopausal BC risk (OR=1.26; 95% CI=1.03-1.54) and increased HR+ BC risk (OR=1.26; 95% CI=1.04-1.52). Regarding prepubertal weight, while those women who were thinner than average showed higher postmenopausal BC risk (OR=1.46; 95% CI=1.20-1.78), associated with HR+ tumors (OR=1.34; 95% CI=1.12-1.61) and with triple negative tumors (OR=1.56; 95% CI=1.03-2.35), those who were heavier than average presented lower premenopausal BC risk (OR=0.64; 95% CI=0.46-0.90) and lower risk of epidermal growth factor receptor positive tumors (OR=0.61; 95% CI=0.40-0.93). These data reflect the importance of hormones and growth factors in the early stages of life, when the mammary gland is in development and therefore more vulnerable to proliferative stimuli.
YR 2015
FD 2015-11-21
LK http://hdl.handle.net/10668/9638
UL http://hdl.handle.net/10668/9638
LA en
DS RISalud
RD Apr 7, 2025