RT Journal Article
T1 A strategy to validate a selection of human effect biomarkers using adverse outcome pathways: Proof of concept for phthalates and reproductive effects.
A1 Baken, Kirsten A
A1 Lambrechts, Nathalie
A1 Remy, Sylvie
A1 Mustieles, Vicente
A1 Rodríguez-Carrillo, Andrea
A1 Neophytou, Christiana M
A1 Olea, Nicolas
A1 Schoeters, Greet
K1 Adverse outcome pathway
K1 Effect biomarkers
K1 Human biomonitoring
K1 Phthalates
K1 Reproductive toxicity
AB Human biomonitoring measures the concentrations of environmental chemicals or their metabolites in body fluids or tissues. Complementing exposure biomarkers with mechanistically based effect biomarkers may further elucidate causal pathways between chemical exposure and adverse health outcomes. We combined information on effect biomarkers previously implemented in human observational studies with mechanisms of action reported in experimental studies and with information from published Adverse Outcome Pathways (AOPs), focusing on adverse reproductive effects of phthalate exposure. Phthalates constitute a group of chemicals that are ubiquitous in consumer products and have been related to a wide range of adverse health effects. As a result of a comprehensive literature search, we present an overview of effect biomarkers for reproductive toxicity that are substantiated by mechanistic information. The activation of several receptors, such as PPARα, PPARγ, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure. Therefore, these receptors appear as promising targets for the development of novel effect biomarkers. The proposed strategy connects the fields of epidemiology and toxicology and may strengthen the weight of evidence in observational studies that link chemical exposures to health outcomes.
YR 2019
FD 2019-05-15
LK http://hdl.handle.net/10668/14042
UL http://hdl.handle.net/10668/14042
LA en
DS RISalud
RD Apr 8, 2025