RT Journal Article
T1 Consumption of Fish Is Not Associated with Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
A1 Zamora-Ros, Raul
A1 Castañeda, Jazmín
A1 Rinaldi, Sabina
A1 Cayssials, Valerie
A1 Slimani, Nadia
A1 Weiderpass, Elisabete
A1 Tsilidis, Konstantinos K
A1 Boutron-Ruault, Marie-Christine
A1 Overvad, Kim
A1 Eriksen, Anne K
A1 Tjønneland, Anne
A1 Kühn, Tilman
A1 Katzke, Verena
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 La Vecchia, Carlo
A1 Kotanidou, Anastasia
A1 Palli, Domenico
A1 Grioni, Sara
A1 Mattiello, Amalia
A1 Tumino, Rosario
A1 Sciannameo, Veronica
A1 Lund, Eiliv
A1 Merino, Susana
A1 Salamanca-Fernández, Elena
A1 Amiano, Pilar
A1 Huerta, José María
A1 Barricarte, Aurelio
A1 Ericson, Ulrika
A1 Almquist, Martin
A1 Hennings, Joakim
A1 Sandström, Maria
A1 Bueno-de-Mesquita, H Bas
A1 Peeters, Petra H
A1 Khaw, Kay-Tee
A1 Wareham, Nicholas J
A1 Schmidt, Julie A
A1 Cross, Amanda J
A1 Riboli, Elio
A1 Scalbert, Augustin
A1 Romieu, Isabelle
A1 Agudo, Antonio
A1 Franceschi, Silvia
K1 EPIC
K1 cohort
K1 fish
K1 intake
K1 thyroid cancer
AB Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk.Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.Methods: EPIC is a cohort of >500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using country-specific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95% CIs adjusted for many potential confounders, including dietary and nondietary factors.Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95% CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence.Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare.
YR 2017
FD 2017-06-07
LK http://hdl.handle.net/10668/11281
UL http://hdl.handle.net/10668/11281
LA en
DS RISalud
RD Apr 10, 2025