RT Journal Article
T1 Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study.
A1 Salto-Alejandre, Sonsoles
A1 Jimenez-Jorge, Silvia
A1 Sabe, Nuria
A1 Ramos-Martinez, Antonio
A1 Linares, Laura
A1 Valerio, Maricela
A1 Martin-Davila, Pilar
A1 Fernsndez-Ruiz, Mario
A1 Fariñas, Maria Carmen
A1 Blanes-Julia, Marino
A1 Vidal, Elisa
A1 Palacios-Baena, Zaira R
A1 Hernandez-Gallego, Roman
A1 Carratala, Jordi
A1 Calderon-Parra, Jorge
A1 Angeles Marcos, Maria
A1 Muñoz, Patricia
A1 Fortun-Abete, Jesus
A1 Aguado, Jose Maria
A1 Arnaiz-Revillas, Francisco
A1 Blanes-Hernandez, Rosa
A1 de la Torre-Cisneros, Julian
A1 Lopez-Cortes, Luis E
A1 Garcia de Vinuesa-Calvo, Elena
A1 Rosso, Clara M
A1 Pachon, Jeronimo
A1 Sanchez-Cespedes, Javier
A1 Cordero, Elisa
K1 Prospective Studies
K1 Risk Factors
K1 Transplant Recipients
K1 Treatment Outcome
AB The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observational cohort study of 210 consecutive SOTRs hospitalized with COVID-19 in 12 Spanish centers from 21 February to 6 May 2020. Data pertaining to demographics, chronic underlying diseases, transplantation features, clinical, therapeutics, and complications were collected. The primary endpoint was a composite of intensive care unit (ICU) admission and/or death. Logistic regression analyses were performed to identify the factors associated with these unfavorable outcomes. Males accounted for 148 (70.5%) patients, the median age was 63 years, and 189 (90.0%) patients had pneumonia. Common symptoms were fever, cough, gastrointestinal disturbances, and dyspnea. The most used antiviral or host-targeted therapies included hydroxychloroquine 193/200 (96.5%), lopinavir/ritonavir 91/200 (45.5%), and tocilizumab 49/200 (24.5%). Thirty-seven (17.6%) patients required ICU admission, 12 (5.7%) suffered graft dysfunction, and 45 (21.4%) died. A shorter interval between transplantation and COVID-19 diagnosis had a negative impact on clinical prognosis. Four baseline features were identified as independent predictors of intensive care need or death: advanced age, high respiratory rate, lymphopenia, and elevated level of lactate dehydrogenase. In summary, this study presents comprehensive information on characteristics and complications of COVID-19 in hospitalized SOTRs and provides indicators available upon hospital admission for the identification of SOTRs at risk of critical disease or death, underlining the need for stringent preventative measures in the early post-transplant period.
PB Public Library of Science
YR 2021
FD 2021-04-13
LK http://hdl.handle.net/10668/17653
UL http://hdl.handle.net/10668/17653
LA en
NO Salto-Alejandre S, Jiménez-Jorge S, Sabé N, Ramos-Martínez A, Linares L, Valerio M, et al. Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study. PLoS One. 2021 Apr 29;16(4):e0250796
DS RISalud
RD Sep 7, 2025