RT Journal Article
T1 Neuroprotective Effects of Diets Containing Olive Oil and DHA/EPA in a Mouse Model of Cerebral Ischemia.
A1 Gonzalo-Gobernado, Rafael
A1 Ayuso, María Irene
A1 Sansone, Loredana
A1 Bernal-Jiménez, Juan José
A1 Ramos-Herrero, Víctor Darío
A1 Sánchez-García, Enrique
A1 Ramos, Teresa L
A1 Abia, Rocío
A1 Muriana, Francisco J G
A1 Bermúdez, Beatriz
A1 Montaner, Joan
K1 DHA
K1 EPA
K1 MUFA
K1 PUFA
K1 SFA
K1 behaviour
K1 cerebral ischemia
K1 middle cerebral artery occlusion (MCAo)
K1 neurological function
K1 neuroprotection
K1 olive oil
K1 omega-3 fatty acids
K1 stroke
AB Stroke is one of the leading causes of death worldwide and while there is increasing evidence that a Mediterranean diet might decrease the risk of a stroke, the effects of dietary fat composition on stroke outcomes have not been fully explored. We hypothesize that the brain damage provoked by a stroke would be different depending on the source of dietary fat. To test this, male C57BL/6J mice were fed for 4 weeks with a standard low-fat diet (LFD), a high-fat diet (HFD) rich in saturated fatty acids (HFD-SFA), an HFD containing monounsaturated fatty acids (MUFAs) from olive oil (HFD-OO), or an HFD containing MUFAs from olive oil plus polyunsaturated fatty acids (PUFAs) docosahexaenoic acid/eicosapentaenoic acid (DHA/EPA) (HFD-OO-ω3). These mice were then subjected to transient middle cerebral artery occlusion (tMCAo). Behavioural tests and histological analyses were performed 24 and/or 48 h after tMCAo in order to elucidate the impact of these diets with different fatty acid profiles on the ischemic lesion and on neurological functions. Mice fed with HFD-OO-ω3 displayed better histological outcomes after cerebral ischemia than mice that received an HFD-SFA or LFD. Furthermore, PUFA- and MUFA-enriched diets improved the motor function and neurological performance of ischemic mice relative to those fed with an LFD or HFD-SFA. These findings support the use of DHA/EPA-omega-3-fatty acid supplementation and olive oil as dietary source of MUFAs in order to reduce the damage and protect the brain when a stroke occurs.
YR 2019
FD 2019-05-18
LK http://hdl.handle.net/10668/13991
UL http://hdl.handle.net/10668/13991
LA en
DS RISalud
RD Apr 9, 2025