RT Journal Article
T1 Multicomponent Analysis of the Differential Induction of Secondary Metabolite Profiles in Fungal Endophytes
A1 Gonzalez-Menendez, Victor
A1 Perez-Bonilla, Mercedes
A1 Perez-Victoria, Ignacio
A1 Martin, Jesus
A1 Munoz, Francisca
A1 Reyes, Fernando
A1 Tormo, Jose R.
A1 Genilloud, Olga
K1 fungal endophytes
K1 epigenetic modifiers
K1 HDAC
K1 DNMT
K1 volcano plots
K1 secondary metabolites
K1 metabolomics
K1 Filamentous fungi
K1 Growth
AB Small molecule histone deacetylase (HDAC) and DNA methyltransferase (DNMT) inhibitors are commonly used to perturb the production of fungal metabolites leading to the induction of the expression of silent biosynthetic pathways. Several reports have described the variable effects observed in natural product profiles in fungi treated with HDAC and DNMT inhibitors, such as enhanced chemical diversity and/or the induction of new molecules previously unknown to be produced by the strain. Fungal endophytes are known to produce a wide variety of secondary metabolites (SMs) involved in their adaptation and survival within higher plants. The plant-microbe interaction may influence the expression of some biosynthetic pathways, otherwise cryptic in these fungi when grown in vitro. The aim of this study was to setup a systematic approach to evaluate and identify the possible effects of HDAC and DNMT inhibitors on the metabolic profiles of wild type fungal endophytes, including the chemical identification and characterization of the most significant SMs induced by these epigenetic modifiers.
PB Mdpi ag
SN 1420-3049
YR 2016
FD 2016-02-01
LK http://hdl.handle.net/10668/19304
UL http://hdl.handle.net/10668/19304
LA en
DS RISalud
RD Apr 19, 2025