RT Journal Article
T1 Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation.
A1 Masip, Jenifer
A1 Jorba, Rosa
A1 López-Dupla, Miguel
A1 Domingo, Pere
A1 Pacheco, Yolanda María
A1 García-Pardo, Graciano
A1 Martínez, Esteban
A1 Viladés, Consuelo
A1 Veloso, Sergi
A1 Alba, Verónica
A1 Olona, Montserrat
A1 Vidal, Francesc
A1 Gómez-Bertomeu, Frederic
A1 Peraire, Joaquim
A1 Rull, Anna
K1 antiretroviral therapy
K1 cardiovascular risk
K1 immunological non-responder
K1 lipoproteins
K1 longitudinal analysis
K1 nuclear magnetic resonance
K1 people living with HIV
AB Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. Of interest, in people living with HIV (PLHIV), predictors of preclinical atherosclerosis and vascular dysfunction may be associated with impaired immune function. We previously stated that immunological non-responders (INR) were at higher CV risk than immunological responders (IR) before starting antiretroviral therapy (ART). Using Liposcale® tests, we characterized the lipoprotein profile from the same cohort of PLHIV at month 12 and month 36 after starting ART, intending to explore what happened with these indicators of CV risk during viral suppression. ART initiation dissipates the differences in lipoprotein-based CV risk markers between INR and IR, and only an increase in the number of HDL-P was found in INR + IR when compared to controls (p = 0.047). Interestingly, CD4+ T-cell counts negatively correlated with medium HDL-P concentrations at month 12 in all individuals (ρ = -0.335, p = 0.003). Longitudinal analyses showed an important increase in LDL-P and HDL-P at month 36 when compared to baseline values in both IR and INR. A proper balance between a proatherogenic and atherogenic environment may be related to the reconstitution of CD4+ T-cell count in PLHIV.
YR 2022
FD 2022-07-22
LK http://hdl.handle.net/10668/21177
UL http://hdl.handle.net/10668/21177
LA en
DS RISalud
RD Apr 11, 2025