RT Journal Article
T1 Prevalence and factors associated with circadian blood pressure patterns in hypertensive patients.
A1 de la Sierra, Alejandro
A1 Redon, Josep
A1 Banegas, José R
A1 Segura, Julián
A1 Parati, Gianfranco
A1 Gorostidi, Manuel
A1 de la Cruz, Juan J
A1 Sobrino, Javier
A1 Llisterri, José L
A1 Alonso, Javier
A1 Vinyoles, Ernest
A1 Pallarés, Vicente
A1 Sarría, Antonio
A1 Aranda, Pedro
A1 Ruilope, Luis M
K1 circadian blood pressure pattern
K1 nocturnal blood pressure dip
K1 cardiovascular risk factors
K1 Factores de riesgo cardiovascular
AB Ambulatory blood pressure (BP) monitoring has become useful in the diagnosis and management of hypertensive individuals. In addition to 24-hour values, the circadian variation of BP adds prognostic significance in predicting cardiovascular outcome. However, the magnitude of circadian BP patterns in large studies has hardly been noticed. Our aims were to determine the prevalence of circadian BP patterns and to assess clinical conditions associated with the nondipping status in groups of both treated and untreated hypertensive subjects, studied separately. Clinical data and 24-hour ambulatory BP monitoring were obtained from 42,947 hypertensive patients included in the Spanish Society of Hypertension Ambulatory Blood Pressure Monitoring Registry. They were 8384 previously untreated and 34,563 treated hypertensives. Twenty-four-hour ambulatory BP monitoring was performed with an oscillometric device (SpaceLabs 90207). A nondipping pattern was defined when nocturnal systolic BP dip was <10% of daytime systolic BP. The prevalence of nondipping was 41% in the untreated group and 53% in treated patients. In both groups, advanced age, obesity, diabetes mellitus, and overt cardiovascular or renal disease were associated with a blunted nocturnal BP decline (P<0.001). In treated patients, nondipping was associated with the use of a higher number of antihypertensive drugs but not with the time of the day at which antihypertensive drugs were administered. In conclusion, a blunted nocturnal BP dip (the nondipping pattern) is common in hypertensive patients. A clinical pattern of high cardiovascular risk is associated with nondipping, suggesting that the blunted nocturnal BP dip may be merely a marker of high cardiovascular risk.
PB American Heart Association
SN 0194-911X
YR 2009
FD 2009-03
LK http://hdl.handle.net/10668/485
UL http://hdl.handle.net/10668/485
LA en
NO de la Sierra A, Redon J, Banegas JR, Segura J, Parati G, Gorostidi M, et al. Prevalence and factors associated with circadian blood pressure patterns in hypertensive patients. Hypertension. 2009 Mar; 53(3):466-72
NO Comment in Timing of antihypertensive therapy and circadian blood pressure pattern. [Hypertension. 2009] Timing of antihypertensive therapy and circadian blood pressure pattern. Almirall J, Martínez-Ocaña JC, Comas L. Hypertension. 2009 Jun; 53(6):e41; author reply e42. Epub 2009 May 4.Dipping comes of age: the importance of nocturnal blood pressure. [Hypertension. 2009]. Dipping comes of age: the importance of nocturnal blood pressure.O'Brien E. Hypertension. 2009 Mar; 53(3):446-7. Epub 2009 Jan 26.Nondipping in patients with hypertension. [Hypertension. 2009]
DS RISalud
RD Apr 7, 2025