TY  - JOUR
AU  - Unciti-Broceta, Juan D
AU  - Arias, José L
AU  - Maceira, José
AU  - Soriano, Miguel
AU  - Ortiz-González, Matilde
AU  - Hernández-Quero, José
AU  - Muñóz-Torres, Manuel
AU  - de Koning, Harry P
AU  - Magez, Stefan
AU  - Garcia-Salcedo, José A
PY  - 2015
DO  - 10.1371/journal.ppat.1004942
UR  - http://hdl.handle.net/10668/2312
T2  - PLoS Pathogens
AB  - African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite Trypanosoma brucei. Current therapies are characterized by high drug toxicity and increasing drug resistance mainly associated with loss-of-function mutations...
LA  - en
PB  - Public Library of Science
KW  - Anticuerpos antiprotozoarios
KW  - Modelos animales de enfermedad
KW  - Portadores de fármacos
KW  - Resistencia a medicamentos
KW  - Ensayo de cambio de movilidad electroforética
KW  - Concentración 50 inhibidora
KW  - Ratones consanguíneos C57BL
KW  - Terapia molecular dirigida
KW  - Nanopartículas
KW  - Pentamidina
KW  - Reacción en cadena en tiempo real de la polimerasa
KW  - Tripanocidas
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Protozoan
KW  - Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Chitin::Chitosan
KW  - Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal
KW  - Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Dosage Forms::Drug Carriers
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Electrophoresis::Electrophoretic Mobility Shift Assay
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Toxicity Tests::Inhibitory Concentration 50
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Molecular Targeted Therapy
KW  - Medical Subject Headings::Technology, Industry, Agriculture::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amidines::Benzamidines::Pentamidine
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Real-Time Polymerase Chain Reaction
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiparasitic Agents::Antiprotozoal Agents::Trypanocidal Agents
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
TI  - Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis.
TY  - research article
ER  -