RT Journal Article
T1 Mucus hypersecretion in asthma is associated with rhinosinusitis, polyps and exacerbations.
A1 Martínez-Rivera, Carlos
A1 Crespo, Astrid
A1 Pinedo-Sierra, Celia
A1 García-Rivero, Juan L
A1 Pallarés-Sanmartín, Abel
A1 Marina-Malanda, Núria
A1 Pascual-Erquicia, Silvia
A1 Padilla, Alicia
A1 Mayoralas-Alises, Sagrario
A1 Plaza, Vicente
A1 López-Viña, Antolín
A1 Picado, César
K1 Anosmia
K1 Asthma
K1 Asthma phenotype
K1 Mucus hypersecretion
K1 Nasal polyps
K1 Rhinosinusitis
AB Bronchial hypersecretion is a poorly studied symptom in asthma. The aim of the study was to determine the specific characteristics of asthmatics with bronchial hypersecretion. A total of 142 asthmatics (21.8% men; mean age 49.8 years) were prospectively followed for one year. Mucus hypersecretion was clinically classified into two severity categories: daily sputum production and frequent expectoration but not every day. Clinical and pulmonary function variables associated with mucus hypersecretion were assessed by multiple logistic regression analysis. Daily cough was recorded in 28.9% of patients and sputum production daily or most of the days in 52.1%. Patients with mucus hypersecretion had more dyspnoea, poorer asthma control and quality of life, had suffered from more exacerbations and showed anosmia associated with chronic rhinosinusitis and nasal polyposis more frequently. Factors associated to mucus hypersecretion were anosmia, one exacerbation or more in the previous year and FEV1/FVC  Mucus hypersecretion is frequent in patients with asthma, and is associated with chronic upper airways disease, airway obstruction, poor asthma control and more exacerbations.
YR 2018
FD 2018-01-03
LK http://hdl.handle.net/10668/12096
UL http://hdl.handle.net/10668/12096
LA en
DS RISalud
RD Apr 10, 2025