RT Journal Article
T1 Venetoclax combination therapy with hypomethylating agents in young adults with relapsed/refractory acute myeloid leukaemia.
A1 Báez-Gutiérrez, Nerea
A1 Rodríguez-Ramallo, Héctor
A1 Moreno, María Antonia-Pérez
A1 Arboli, Eduardo-Rodriguez
A1 Abdel-Kader Martín, Laila
K1 acute myeloid leukaemia
K1 hypomethylating agent
K1 refractory
K1 relapsed
K1 venetoclax
K1 young patients
AB In recent years, one of the most successful advances in treating acute myeloid leukaemia (AML) has been the combination of the B-cell lymphoma 2 (BCL-2) inhibitor venetoclax with hypomethylating agents (decitabine or azacytidine). This combination treatment has an accelerated approval by the Food and Drug Administration for newly diagnosed AML adults who are 75 years of age or older or who have comorbidities and are not eligible to receive intensive induction chemotherapy. AML is the most common form of acute leukaemia in adults, with a median age at diagnosis of 68 years. Consequently, most of the patients included in the studies are elderly. Traditionally, young patients achieve higher remission rates compared with the elderly AML population. Although venetoclax combination therapy could become a treatment option for treating young patients with relapsed/refractory AML, this regimen has not been systematically tested in this setting. In this study, we summarize the currently available evidence on the treatment of venetoclax in combination with hypomethylating agents for the treatment of young relapsed/refractory AML patients, in addition to our experience in clinical practice with two case reports. Venetoclax, combined with hypomethylating agents, seems to be an effective option for young relapsed/refractory AML patients. However, due to the poor quality of the evidence, additional well-designed studies with greater numbers of patients are needed to confirm the effectiveness and safety of venetoclax combination regimens for this population.
SN 2040-6207
YR 2021
FD 2021-08-28
LK https://hdl.handle.net/10668/27472
UL https://hdl.handle.net/10668/27472
LA en
DS RISalud
RD Apr 14, 2025