RT Journal Article
T1 Layer-Specific Global Longitudinal Strain Predicts Arrhythmic Risk in Arrhythmogenic Cardiomyopathy
A1 Segura-Rodriguez, Diego
A1 Bermudez-Jimenez, Francisco Jose
A1 Gonzalez-Camacho, Lorena
A1 Moreno Escobar, Eduardo
A1 Garcia-Orta, Rocio
A1 Alcala-Lopez, Juan Emilio
A1 Bautista Paves, Alicia
A1 Oyonarte-Ramirez, Jose Manuel
A1 Lopez-Fernandez, Silvia
A1 Alvarez, Miguel
A1 Tercedor, Luis
A1 Jimenez-Jaimez, Juan
K1 sudden cardiac death (SCD)
K1 late gadolinium enhanced
K1 non-sustained ventricular tachycardia
K1 arrhythmogenic cardiomyopathy (ACM)
K1 global longitudinal strain
K1 Right-ventricular cardiomyopathy/dysplasia
K1 Echocardiographic reference ranges
K1 Speckle-tracking echocardiography
K1 Myocardial strain
K1 Task-force
K1 Diagnosis
K1 Mutation
K1 Association
K1 Standard
AB Background: Arrhythmogenic cardiomyopathy (AC) is a life-threatening disease which predispose to malignant arrhythmias and sudden cardiac death (SCD) in the early stages of the disease. Risk stratification relies on the electrical, genetic, and imaging data. Our study aimed to investigate how myocardial deformation parameters may identify the subjects at risk of known predictors of major ventricular arrhythmias.Methods: A cohort of 45 subjects with definite or borderline diagnosis of AC was characterized using the advanced transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) and divided into the groups according to the potential arrhythmic risk markers, such as non-sustained ventricular tachycardia (NSVT), late gadolinium enhancement (LGE), and genetic status. Layer-specific global longitudinal strain (GLS) by TTE 2D speckle tracking was compared in patients with and without these arrhythmic risk markers.Results: In this study, 23 (51.1%) patients were men with mean age of 43 +/- 16 years. Next-generation sequencing identified a potential pathogenic mutation in 39 (86.7%) patients. Thirty-nine patients presented LGE (73.3%), mostly located at the subepicardial-to-mesocardial layers. A layer-specific-GLS analysis showed worse GLS values at the epicardial and mesocardial layers in the subjects with NSVT and LGE. The epicardial GLS values of -15.4 and -16.1% were the best cut-off values for identifying the individuals with NSVT and LGE, respectively, regardless of left ventricular ejection fraction (LVEF).Conclusions: The layer-specific GLS assessment identified the subjects with high-risk arrhythmic features in AC, such as NSVT and LGE. An epicardial GLS may emerge as a potential instrument for detecting the subjects at risk of SCD in AC.
PB Frontiers media sa
SN 2297-055X
YR 2021
FD 2021-11-15
LK https://hdl.handle.net/10668/26209
UL https://hdl.handle.net/10668/26209
LA en
DS RISalud
RD Apr 9, 2025