RT Journal Article
T1 Effects of Different Doses of Exercise on Inflammation Markers Among Adolescents With Overweight/Obesity: HEPAFIT Study.
A1 Ramírez-Vélez, Robinson
A1 García-Hermoso, Antonio
A1 Correa-Rodríguez, María
A1 Fernández-Irigoyen, Joaquín
A1 Palomino-Echeverría, Sara
A1 Santamaría, Enrique
A1 Correa-Bautista, Jorge Enrique
A1 González-Ruíz, Katherine
A1 Izquierdo, Mikel
K1 exercise
K1 inflammation
K1 obesity
K1 youth
AB Obesity-related metabolic risk factors in adolescents who are overweight/obese may be associated with systemic low-grade inflammation; therefore, we investigated whether 6 months of exercise training altered markers of inflammation. Secondary analyses of a randomized controlled exercise-based intervention trial (September 2017-December 2018). Adolescents aged 11 to 17 years (Tanner stage II-V), 70% girls, with a body mass index z-score at or above the 85th percentile, and/or with excess of adiposity (body fat ≥ 30%). The participants were randomly assigned to the following 4 groups for 6 months: (1) standard physical education lessons, as a control (CTRL); (2) high-intensity physical education class (HIPE); (3) low-to-moderate intensity physical education class (LIPE); (4) a combined group (PLUS). Inflammatory markers and immune molecules including chemokines, cytokines, and growth factors (n = 65 biomarkers) were determined by cytokine antibody array. Of the 120 randomly assigned participants, 95 were included in the analysis. Considering these 22 proteins, the LIPE group shows statistical significance in 9 proteins with log-fold change (logFC) and P  Implementing a 6-month physical exercise program in overweight/obese adolescents, based on LIPE and PLUS groups, significantly change several circulating inflammatory levels. Interventions involving supervised physical exercise may reduce the associated effects of systemic low-grade inflammation, thus preventing the development of obesity-related metabolic diseases in adolescents with overweight/obesity.
YR 2022
FD 2022
LK http://hdl.handle.net/10668/20391
UL http://hdl.handle.net/10668/20391
LA en
DS RISalud
RD Apr 5, 2025