RT Conference Proceedings
T1 ANALYSIS OF INTESTINAL MICROBIOTA IN PATIENTS WITH OSTEOPOROSIS SECONDARY TO RHEUMATOID ARTHRITIS
A1 Cabezas-Lucena, A. M.
A1 Morales-Aguila, M.
A1 Ruiz-Limon, P.
A1 Moreno-Indias, I.
A1 Mena-Vazquez, N.
A1 Arija, S. Manrique
A1 Fernandez-Nebro, A.
K1 Rheumatoid Factor
K1 Absorptiometry, Photon
K1 Antirheumatic Agents
K1 Gastrointestinal Microbiome
K1 Arthritis, Rheumatoid
AB Objectives: To analyse the intestinal microbiota in patients with osteoporosis (OP) secondary to rheumatoid arthritis (RA). Methods: Design: A cross-sectional observational study nested in a prospective cohort of incident RA patients. Patients: Patients with RA (ACR/EULAR 2010) from a prospective baseline cohort (incident cases between 2007-2011), >16 years, from whom information on bone mineral densitometry (BMD) was collected. Protocol: All subjects were evaluated in a specialized outpatient unit. Clinical-analytical variables of the cut-off date and clinical history were registered. Blood, urine, and faeces samples were obtained from all subjects. A BMD was done by dual energy X-ray absorptiometry (DXA) for osteoporosis diagnosis. Variables: Dependent variable: osteoporosis according to World Health Organization (WHO) definitions. The fecal microbiota (continuous var., 0-100%) was analysed using the Ion Torrent S5 next-generation sequencing platform, and the sequences obtained were processed using the QIIME2 (Quantitative Insights Into Microbial Ecology 2) software. Other variables included demographic characteristics, comorbidities, inflammatory activity measured by mean accumulated Disease Activity Score-28 (DAS-28) throughout the disease, severity variables: smoking, erosions, anticitrullinated peptide antibody (ACPA) titres, rheumatoid factor (RF), and physical function measured by HAQ. Treatment with bDMARD (biological disease-modifying antirheumatic drug) and/or sDMARD (synthetic disease-modifying antirheumatic drug).
PB Bmj publishing group
SN 0003-4967
YR 2022
FD 2022-06-01
LK http://hdl.handle.net/10668/20104
UL http://hdl.handle.net/10668/20104
LA en
NO Cabezas-Lucena, A. M., Morales-Águila, M., Ruiz-Limon, P., Moreno-Indias, I., Mena-Vázquez, N., Arija, S. M., et al. (2022). AB0301 ANALYSIS OF INTESTINAL MICROBIOTA IN PATIENTS WITH OSTEOPOROSIS SECONDARY TO RHEUMATOID ARTHRITIS. Annals Of The Rheumatic Diseases, 81(Suppl 1), 1276-1277. https://doi.org/10.1136/annrheumdis-2022-eular.3608
DS RISalud
RD Apr 18, 2025