RT Journal Article
T1 Increase in CD8+CD158a+ T Cells in Kidney Graft Blood is Associated with Better Renal Function
A1 Caballero, Abelardo
A1 Palma, Eulalia
A1 Ruiz-Esteban, Pedro
A1 Sola, Eugenia
A1 López, Verónica
A1 Fuentes, Laura
A1 Rudas, Edisson
A1 Perea, Lara
A1 Hernández, Domingo
K1 Biopsy, fine-needle
K1 Peripheral blood stem cell transplantation
K1 Receptors, KIR
K1 Adulto
K1 Anciano
K1 Femenino
K1 Citometría de flujo
K1 Humanos
K1 Riñón
K1 Pruebas de función renal
K1 Trasplante de riñón
K1 Estudios longitudinales
K1 Masculino
K1 Mediana edad
K1 Periodo posoperatorio
K1 Factores de tiempo
K1 Linfocitos T CD8-positivos
AB BACKGROUND Studies of liver and heart transplant patients have shown a gradual reconstruction of the CD8 KIR2D+ T cell subpopulations, measured in peripheral blood (PB), associated with better graft acceptance. The kinetics of these populations in kidney transplants, however, is still poorly understood, especially given the lack of studies of blood samples from the kidney graft. MATERIAL AND METHODS Flow cytometry was used to measure CD8+CD158a/b/e T cells in 69 kidney transplant patients who had stable renal function during follow-up. Measurements were made at 3, 6, and 12 months post-transplantation in graft capillary blood extracted by fine needle aspiration puncture (FNAP) and in PB. RESULTS No progressive increase was found in the PB subpopulations. However, the CD8+CD158a+ subsets increased significantly at 12 months in the graft blood versus the PB samples (3.91±4.59 vs. 2.84±4.71; p=0.021). The ratio of the percentage of CD8+CD158a+ cells in graft blood compared to PB at 12 months was associated with better renal function in those patients with a ratio ≥3 (66.6±14.53 vs. 55.7±21.6; p=0.032). CONCLUSIONS An increased ratio of CD8+CD158a+ cells, measured by flow cytometry, between graft blood and PB was associated with improved renal function.
PB Springer Verlag
SN 1425-9524
YR 2017
FD 2017-01-24
LK http://hdl.handle.net/10668/2682
UL http://hdl.handle.net/10668/2682
LA en
NO Caballero A, Palma E, Ruiz-Esteban P, Sola E, López V, Fuentes L, et al. Increase in CD8+CD158a+ T Cells in Kidney Graft Blood is Associated with Better Renal Function. Ann Transplant. 2017; 24;22:35-41.
DS RISalud
RD Apr 8, 2025