RT Journal Article T1 Integrative development of a short screening questionnaire of highly processed food consumption (sQ-HPF). A1 Martinez-Perez, Celia A1 Daimiel, Lidia A1 Climent-Mainar, Cristina A1 Martinez-Gonzalez, Miguel Angel A1 Salas-Salvado, Jordi A1 Corella, Dolores A1 Schröder, Helmut A1 Martinez, Jose Alfredo A1 Alonso-Gomez, Angel M A1 Wärnberg, Julia A1 Vioque, Jesus A1 Romaguera, Dora A1 Lopez-Miranda, Jose A1 Estruch, Ramon A1 Tinahones, Francisco J A1 Lapetra, Jose A1 Serra-Majem, Lluis A1 Bueno-Cavanillas, Aurora A1 Tur, Josep A A1 Sanchez, Vicente Martin A1 Pinto, Xavier A1 Delgado-Rodriguez, Miguel A1 Matia-Martin, Pilar A1 Vidal, Josep A1 Vazquez, Clotilde A1 Ros, Emilio A1 Basterra, Javier A1 Babio, Nancy A1 Guillem-Saiz, Patricia A1 Zomeño, Maria Dolores A1 Abete, Itziar A1 Vaquero-Luna, Jessica A1 Baron-Lopez, Francisco Javier A1 Gonzalez-Palacios, Sandra A1 Konieczna, Jadwiga A1 Garcia-Rios, Antonio A1 Bernal-Lopez, Maria Rosa A1 Santos-Lozano, Jose Manuel A1 Bes-Rastrollo, Maira A1 Khoury, Nadine A1 Saiz, Carmen A1 Perez-Vega, Karla Alejandra A1 Zulet, Maria Angeles A1 Tojal-Sierra, Lucas A1 Ruiz, Zenaida Vázquez A1 Martinez, Maria Angeles A1 Malcampo, Mireia A1 Ordovas, Jose M A1 San-Cristobal, Rodrigo K1 Food processing-based classification K1 Highly processed food K1 NOVA K1 PREDIMED-Plus K1 Questionnaire K1 Ultra-processed food AB Recent lifestyle changes include increased consumption of highly processed foods (HPF), which has been associated with an increased risk of non-communicable diseases (NCDs). However, nutritional information relies on the estimation of HPF consumption from food-frequency questionnaires (FFQ) that are not explicitly developed for this purpose. We aimed to develop a short screening questionnaire of HPF consumption (sQ-HPF) that integrates criteria from the existing food classification systems. Data from 4400 participants (48.1% female and 51.9% male, 64.9 ± 4.9 years) of the Spanish PREDIMED-Plus ("PREvention with MEDiterranean DIet") trial were used for this analysis. Items from the FFQ were classified according to four main food processing-based classification systems (NOVA, IARC, IFIC and UNC). Participants were classified into tertiles of HPF consumption according to each system. Using binomial logistic regression, food groups associated with agreement in the highest tertile for at least two classification systems were chosen as items for the questionnaire. ROC analysis was used to determine cut-off points for the frequency of consumption of each item, from which a score was calculated. Internal consistency of the questionnaire was assessed through exploratory factor analysis (EFA) and Cronbach's analysis, and agreement with the four classifications was assessed with weighted kappa coefficients. Regression analysis identified 14 food groups (items) associated with high HPF consumption for at least two classification systems. EFA showed that items were representative contributors of a single underlying factor, the "HPF dietary pattern" (factor loadings around 0.2). We constructed a questionnaire asking about the frequency of consumption of those items. The threshold frequency of consumption was selected using ROC analysis. Comparison of the four classification systems and the sQ-HPF showed a fair to high agreement. Significant changes in lifestyle characteristics were detected across tertiles of the sQ-HPF score. Longitudinal changes in HPF consumption were also detected by the sQ-HPF, concordantly with existing classification systems. We developed a practical tool to measure HPF consumption, the sQ-HPF. This may be a valuable instrument to study its relationship with NCDs. Retrospectively registered at the International Standard Randomized Controlled Trial Registry ( ISRCTN89898870 ) on July 24, 2014. PB BioMed Central YR 2021 FD 2021-12-14 LK http://hdl.handle.net/10668/20329 UL http://hdl.handle.net/10668/20329 LA en NO Martinez-Perez C, Daimiel L, Climent-Mainar C, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Integrative development of a short screening questionnaire of highly processed food consumption (sQ-HPF). Int J Behav Nutr Phys Act. 2022 Jan 24;19(1):6 DS RISalud RD Apr 6, 2025