RT Journal Article
T1 Implications of irradiating the subventricular zone stem cell niche.
A1 Capilla-Gonzalez, Vivian
A1 Bonsu, Janice M
A1 Redmond, Kristin J
A1 Garcia-Verdugo, Jose Manuel
A1 Quiñones-Hinojosa, Alfredo
K1 Subventricular zone
K1 Neural stem cells
K1 Radiation
K1 Neurogenesis
K1 Brain tumor
K1 Células-madre neurales
K1 Neoplasias encefálicas
K1 Neurogénesis
K1 Radioterapia
AB Radiation therapy is a standard treatment for brain tumor patients. However, it comes with side effects, such as neurological deficits. While likely multi-factorial, the effect may in part be associated with the impact of radiation on the neurogenic niches. In the adult mammalian brain, the neurogenic niches are localized in the subventricular zone (SVZ) of the lateral ventricles and the dentate gyrus of the hippocampus, where the neural stem cells (NSCs) reside. Several reports showed that radiation produces a drastic decrease in the proliferative capacity of these regions, which is related to functional decline. In particular, radiation to the SVZ led to a reduced long-term olfactory memory and a reduced capacity to respond to brain damage in animal models, as well as compromised tumor outcomes in patients. By contrast, other studies in humans suggested that increased radiation dose to the SVZ may be associated with longer progression-free survival in patients with high-grade glioma. In this review, we summarize the cellular and functional effects of irradiating the SVZ niche. In particular, we review the pros and cons of using radiation during brain tumor treatment, discussing the complex relationship between radiation dose to the SVZ and both tumor control and toxicity.
PB Elsevier
SN 1873-5061
YR 2016
FD 2016-03
LK http://hdl.handle.net/10668/2260
UL http://hdl.handle.net/10668/2260
LA en
NO Capilla-Gonzalez V, Bonsu JM, Redmond KJ, Garcia-Verdugo JM, Quiñones-Hinojosa A. Implications of irradiating the subventricular zone stem cell niche. Stem Cell Res. 2016; 16(2):387-96
NO Journal Article; Review;
DS RISalud
RD Apr 7, 2025