RT Journal Article
T1 The Effect of Body Fat Distribution on Systemic Sclerosis.
A1 Villanueva-Martin, Gonzalo
A1 Acosta-Herrera, Marialbert
A1 Kerick, Martin
A1 López-Isac, Elena
A1 Simeón, Carmen P
A1 Callejas, José L
A1 Assassi, Shervin
A1 Beretta, Lorenzo
A1 SSc Group, International
A1 Asig, Australian Scleroderma Interest Group
A1 Allanore, Yannick
A1 Proudman, Susanna M
A1 Nikpour, Mandana
A1 Fonseca, Carmen
A1 Denton, Christopher P
A1 Radstake, Timothy R D J
A1 Mayes, Maureen D
A1 Jiang, Xia
A1 Martin, Javier
A1 Bossini-Castillo, Lara
K1 mendelian randomization
K1 obesity
K1 systemic sclerosis
AB Obesity contributes to a chronic proinflammatory state, which is a known risk factor to develop immune-mediated diseases. However, its role in systemic sclerosis (SSc) remains to be elucidated. Therefore, we conducted a two-sample mendelian randomization (2SMR) study to analyze the effect of three body fat distribution parameters in SSc. As instrumental variables, we used the allele effects described for single nucleotide polymorphisms (SNPs) in different genome-wide association studies (GWAS) for SSc, body mass index (BMI), waist-to-hip ratio (WHR) and WHR adjusted for BMI (WHRadjBMI). We performed local (pHESS) and genome-wide (LDSC) genetic correlation analyses between each of the traits and SSc and we applied several Mendelian randomization (MR) methods (i.e., random effects inverse-variance weight, MR-Egger regression, MR pleiotropy residual sum and outlier method and a multivariable model). Our results show no genetic correlation or causal relationship between any of these traits and SSc. Nevertheless, we observed a negative causal association between WHRadjBMI and SSc, which might be due to the effect of gastrointestinal complications suffered by the majority of SSc patients. In conclusion, reverse causality might be an especially difficult confounding factor to define the effect of obesity in the onset of SSc.
SN 2077-0383
YR 2022
FD 2022-10-12
LK http://hdl.handle.net/10668/21358
UL http://hdl.handle.net/10668/21358
LA en
DS RISalud
RD Apr 10, 2025