RT Journal Article
T1 Two-year outcomes after percutaneous coronary intervention with drug-eluting stents or bare-metal stents in elderly patients with coronary artery disease.
A1 Lafont, Alexandre
A1 Sinnaeve, Peter R
A1 Cuisset, Thomas
A1 Cook, Stéphane
A1 Sideris, Giorgios
A1 Kedev, Sasko
A1 Carrie, Didier
A1 Hovasse, Thomas
A1 Garot, Philippe
A1 El Mahmoud, Rami
A1 Spaulding, Christian
A1 Helft, Gérard
A1 Diaz Fernandez, José F
A1 Brugaletta, Salvatore
A1 Pinar-Bermudez, Eduardo
A1 Ferre, Josepa Mauri
A1 Commeau, Philippe
A1 Teiger, Emmanuel
A1 Bogaerts, Kris
A1 Sabate, Manel
A1 Morice, Marie Claude
A1 Varenne, Olivier
A1 SENIOR investigators, 
K1 PCI
K1 bare metal stents
K1 drug eluting stents
K1 elderly patients
K1 short DAPT
AB Report the results at 2 years of the patients included in the SENIOR trial. Patients above 75 years of age represent a fast-growing population in the cathlab. In the SENIOR trial, patients treated by percutaneous coronary intervention (PCI) with drug eluting stent (DES) and a short duration of P2Y12 inhibitor (1 and 6 months for stable and unstable coronary syndromes, respectively) compared with bare metal stents (BMS) was associated with a 29% reduction in the rate of all-cause mortality, myocardial infarction (MI), stroke, and ischaemia-driven target lesion revascularization (ID-TLR) at 1 year. The results at 2 years are reported here. We randomly assigned 1,200 patients (596[50%] to the DES group and 604[50%] to the BMS group). At 2 years, the composite endpoint of all-cause mortality, MI, stroke and ID-TLR had occurred in 116 (20%) patients in the DES group and 131 (22%) patients in the BMS group (RR 0.90 [95%CI 0.72-1.13], p = .37). IDTLR occurred in 14 (2%) patients in the DES group and 41 (7%) patients in the BMS group (RR 0.35 [95%CI 0.16-0.60], p = .0002). Major bleedings (BARC 3-5) occurred in 27(5%) patients in both groups (RR 1.00, [95%CI 0.58-1.75], p = .99). Stent thrombosis rates were low and similar between DES and BMS (0.8 vs 1.3%, (RR 0.52 [95%CI 0.01-1.95], p = .27). Among elderly PCI patients, a strategy combining a DES together with a short duration of DAPT is associated with a reduction in revascularization up to 2 years compared with BMS with very few late events and without any increased in bleeding complications or stent thrombosis.
YR 2020
FD 2020-08-06
LK http://hdl.handle.net/10668/16060
UL http://hdl.handle.net/10668/16060
LA en
DS RISalud
RD Apr 8, 2025